1. Membrane Transporter/Ion Channel
  2. TRP Channel

ML204 hydrochloride (Synonyms: ML-204 hydrochloride; ML 204 hydrochloride)

Cat. No.: HY-12949A Purity: 99.37%
Handling Instructions

ML204 is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM. exhibit 19-fold selectivity against TRPC6 channels in similar fluorescent assays.

For research use only. We do not sell to patients.
ML204 hydrochloride Chemical Structure

ML204 hydrochloride Chemical Structure

CAS No. :

Size Price Stock Quantity
10 mM * 1 mL in Water $77 In-stock
5 mg $70 In-stock
10 mg $100 In-stock
50 mg $320 In-stock
100 mg $520 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of ML204 hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

Description

ML204 is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM. exhibit 19-fold selectivity against TRPC6 channels in similar fluorescent assays. target: ML204 IC50: 0.96 uM In vitro: ML204 inhibited TRPC4β-mediated intracellular Ca2+ rise. ML204 at 10 μm showed >50% inhibition in only 7 of 68 binding assays for 68 GPCRs, ion channels, and transporters.[1] ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels. [2] In vivo: The selectivity of ML204 show no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons.[1]

M.Wt

262.78

Formula

C₁₅H₁₉ClN₂

CAS No.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 30 mg/mL

Purity: 99.37%

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ML204 hydrochloride
Cat. No.:
HY-12949A
Quantity: