1. Membrane Transporter/Ion Channel
  2. TRP Channel

ML204 hydrochloride 

Cat. No.: HY-12949A Purity: 99.37%
Handling Instructions

ML204 is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM. exhibit 19-fold selectivity against TRPC6 channels in similar fluorescent assays.

For research use only. We do not sell to patients.
ML204 hydrochloride Chemical Structure

ML204 hydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in Water USD 92 In-stock
5 mg USD 84 In-stock
10 mg USD 120 In-stock
50 mg USD 384 In-stock
100 mg USD 624 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of ML204 hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

ML204 is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM. exhibit 19-fold selectivity against TRPC6 channels in similar fluorescent assays. target: ML204 IC50: 0.96 uM In vitro: ML204 inhibited TRPC4β-mediated intracellular Ca2+ rise. ML204 at 10 μm showed >50% inhibition in only 7 of 68 binding assays for 68 GPCRs, ion channels, and transporters.[1] ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels. [2] In vivo: The selectivity of ML204 show no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons.[1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.8055 mL 19.0273 mL 38.0546 mL
5 mM 0.7611 mL 3.8055 mL 7.6109 mL
10 mM 0.3805 mL 1.9027 mL 3.8055 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

262.78

Formula

C₁₅H₁₉ClN₂

SMILES

CC1=CC(N2CCCCC2)=NC3=CC=CC=C13.Cl[H]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
ML204 hydrochloride
Cat. No.:
HY-12949A
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