1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. ML204 hydrochloride

ML204 hydrochloride 

Cat. No.: HY-12949A Purity: 99.64%
Handling Instructions

ML204 hydrochloride is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM.

For research use only. We do not sell to patients.

ML204 hydrochloride Chemical Structure

ML204 hydrochloride Chemical Structure

CAS No. : 2070015-10-8

Size Price Stock Quantity
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ML204 hydrochloride is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM. exhibit 19-fold selectivity against TRPC6 channels in similar fluorescent assays. target: ML204 IC50: 0.96 uM In vitro: ML204 inhibited TRPC4β-mediated intracellular Ca2+ rise. ML204 at 10 μm showed >50% inhibition in only 7 of 68 binding assays for 68 GPCRs, ion channels, and transporters.[1] ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels. [2] In vivo: The selectivity of ML204 show no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons.[1]

Molecular Weight

262.78

Formula

C₁₅H₁₉ClN₂

CAS No.

2070015-10-8

SMILES

CC1=CC(N2CCCCC2)=NC3=CC=CC=C13.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 30 mg/mL (114.16 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8055 mL 19.0273 mL 38.0546 mL
5 mM 0.7611 mL 3.8055 mL 7.6109 mL
10 mM 0.3805 mL 1.9027 mL 3.8055 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ML204ML 204ML-204TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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Product name:
ML204 hydrochloride
Cat. No.:
HY-12949A
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