1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. ML204 hydrochloride

ML204 hydrochloride 

Cat. No.: HY-12949A Purity: 99.81%
Handling Instructions

ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels.

For research use only. We do not sell to patients.

ML204 hydrochloride Chemical Structure

ML204 hydrochloride Chemical Structure

CAS No. : 2070015-10-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 280 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of ML204 hydrochloride:

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2].

IC50 & Target[1][2]

TRPC4

 

TRPC5

 

In Vitro

ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation[1].
ML204 hydrochloride blocks TRPC4β activity induced through either Gi/o stimulation by μ-opioid, 5HT1A serotonin, and M2 muscarinic receptors or Gq/11 stimulation by the endogenous M3-like muscarinic receptors[1].
ML204 hydrochloride blocks LPS-induced TRPC5 channel activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML204 hydrochloride (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nonfasted male C57BL/6 (2-3 months)[4]
Dosage: 1 mg/kg
Administration: Subcutaneous injection, twice a day, for 5 days (prior to LPS injection)
Result: Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
Molecular Weight

262.78

Formula

C₁₅H₁₉ClN₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 30 mg/mL (114.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8055 mL 19.0273 mL 38.0546 mL
5 mM 0.7611 mL 3.8055 mL 7.6109 mL
10 mM 0.3805 mL 1.9027 mL 3.8055 mL
*Please refer to the solubility information to select the appropriate solvent.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ML204 hydrochloride
Cat. No.:
HY-12949A
Quantity:
MCE Japan Authorized Agent: