1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. ML204

ML204 

Cat. No.: HY-12949 Purity: 99.24%
Handling Instructions

ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels.

For research use only. We do not sell to patients.

ML204 Chemical Structure

ML204 Chemical Structure

CAS No. : 5465-86-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Oil + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Oil
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2].

IC50 & Target

TRPC4

 

TRPC5

 

In Vitro

ML204 inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation[1].
ML204 blocks TRPC4β activity induced through either Gi/o stimulation by μ-opioid, 5HT1A serotonin, and M2 muscarinic receptors or Gq/11 stimulation by the endogenous M3-like muscarinic receptors[1].
ML204 blocks LPS-induced TRPC5 channel activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML204 (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nonfasted male C57BL/6 (2-3 months)[4]
Dosage: 1 mg/kg
Administration: Subcutaneous injection, twice a day, for 5 days (prior to LPS injection)
Result: Induced mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
Molecular Weight

226.32

Formula

C₁₅H₁₈N₂

CAS No.
SMILES

CC1=CC(N2CCCCC2)=NC3=CC=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (220.93 mM; Need ultrasonic)

DMSO : ≥ 37 mg/mL (163.49 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4185 mL 22.0926 mL 44.1852 mL
5 mM 0.8837 mL 4.4185 mL 8.8370 mL
10 mM 0.4419 mL 2.2093 mL 4.4185 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (11.05 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

ML204ML 204ML-204TRP ChannelTransient receptor potential channelsionchannelsmembranebiophysicstransportreceptorregulationtransientpotentialcanonicalTRPInhibitorinhibitorinhibit

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Product Name:
ML204
Cat. No.:
HY-12949
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