5465-86-1
5465-86-1
Chemical Structure
ML204
- CAS No.: 5465-86-1
- Formula:C15H18N2
- Molecular Weight:226.32
IUPAC Name: 4-methyl-2-(piperidin-1-yl)quinoline
InChIKey: USYRQXDHKXGTCK-UHFFFAOYSA-N
SMILES: CC1=CC(N2CCCCC2)=NC3=CC=CC=C13
Biological Activity: ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML204 | 98.45% | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels. | ||||||||||||||||||||
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4-Methyl-2-(1-piperidinyl)-quinoline-d10 | 4-Methyl-2-(1-piperidinyl)-quinoline-d10 is the deuterium labeled ML204 (HY-12949). ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-12949AML204 hydrochloride -
Similarity Score 0.78
HY-169547ETNK-IN-1 -
Similarity Score 0.68
HY-121951N-Methylquipazine -
Similarity Score 0.68
HY-W028142Quipazine -
Similarity Score 0.66
HY-169565ETNK-IN-2 -
Similarity Score 0.64
HY-19172349U85 hydrochloride -
Similarity Score 0.64
HY-162595BDM88855 -
Similarity Score 0.63
HY-162595ABDM88855 hydrochloride -
Similarity Score 0.62
HY-W988549Zindotrine -
Explore the MedChemAI to find more analogs
References
- [1]. Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46. [Content Brief]
- [2]. Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program [Internet]. [Content Brief]
