Quipazine 

Quipazine is a 5-HT agonist with a K_i value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC₅₀ of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research^[1][2][3][4].

Quipazine shows binding efficacy to 5-HT1 and 5-HT2 with K_i values of 230 nM^[3].
Quipazine displaces [3H]GR65630 from 5-HT3R in rat entorhinal cortex with a K_i value of 1.4 nM^[3].
Quipazine shows antagonistic properties on the rat vagus nerve with pIC₅₀ value of 6.1, 6.49 and 6.17 for 5-HT2, 5-HT1 and inhibition of 5-HT release^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quipazine (2.5, 5 and 7.5 mg/kg, one dose for once; i.p.) affects dietary self-selection of different macronutrient diets in male and female rats^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

213.28

Solid

C₁₃H₁₅N₃

4774-24-7

C1(N2CCNCC2)=NC3=CC=CC=C3C=C1

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Mok E, et al. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25.  [Content Brief]

  [2]. Günther S, et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 May 7;372(6542):642-646.  [Content Brief]

  [3]. Glennon RA, et al. 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80.  [Content Brief]

  [4]. Ireland SJ, Tyers MB. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol. 1987 Jan;90(1):229-38.  [Content Brief]