2070015-10-8
2070015-10-8
Chemical Structure
ML204 hydrochloride
- CAS No.: 2070015-10-8
- Formula:C15H19ClN2
- Molecular Weight:262.78
IUPAC Name: 4-methyl-2-(piperidin-1-yl)quinoline hydrochloride
InChIKey: QCABWRXQHZUBPW-UHFFFAOYSA-N
SMILES: CC1=CC(N2CCCCC2)=NC3=CC=CC=C13.Cl[H]
Biological Activity: ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML204 hydrochloride | 99.74% | ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels. | ||||||||||||||||||||
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References
- [1]. Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46. [Content Brief]
- [2]. Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program. [Content Brief]
Keywords
