1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Hyp9

Hyp9 

Cat. No.: HY-N10756
Handling Instructions

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI).

For research use only. We do not sell to patients.

Hyp9 Chemical Structure

Hyp9 Chemical Structure

CAS No. : 3118-34-1

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Description

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI)[1].

In Vitro

HYP9 (0, 1, 5, 10, 15, 20, 25, 30 µM; 72 h) inhibits astrocyte proliferation in a dose-dependent manner[1].
HYP9 dramatically suppresses AP4 overexpression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: CTX-TNA2 rat astrocytes
Concentration: 0, 1, 5, 10, 15, 20, 25, 30 µM
Incubation Time: 72 h
Result: Significantly inhibit astrocyte proliferation at 5-30 µM.
In Vivo

HP9 (intrathecally; 5 μg; 1, 3, 5, and 7 days) inhibits astrocyte activation and proliferation by inhibiting AQP4 in SCl rats in vivo models and that it preserves neuronal survival and functional recovery after SCI[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley Rats (180-220 g; adult female)[1]
Dosage: 5 μg
Administration: Intrathecally; 1, 3, 5, and 7 days
Result: Inhibited activation and proliferation of astrocytes in a rat SCI model.
Reduced apoptosis and promotes neuronal survival in SCI rats by TRPC6/AQP4 signaling pathway.
Facilitated functional motor recovery via TRPC6/AQP4 signaling pathway in SCI rats.
Molecular Weight

322.40

Formula

C18H26O5

CAS No.
SMILES

O=C(CCCCC)C1=C(C=C(C(C(CCCCC)=O)=C1O)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Hyp9
Cat. No.:
HY-N10756
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