2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. SAR7334

SAR7334 

Cat. No.: HY-15699 Purity: 99.88%
COA Handling Instructions

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

For research use only. We do not sell to patients.

SAR7334 Chemical Structure

SAR7334 Chemical Structure

CAS No. : 1333210-07-3

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Customer Review

Based on 15 publication(s) in Google Scholar

Other Forms of SAR7334:

SAR7334 Related Antibodies

Top Publications Citing Use of Products

    SAR7334 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Oct 3;9(10):1015.  [Abstract]

    HK-2 cells are treated with different concentrations of SAR7334 for 12 h. Representative western blot images and the relative quantification of LC3-II are shown.

    View All TRP Channel Isoform Specific Products:

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    TRPC TRPM TRPV TRPA TRPML

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

    IC50 & Target

    IC50: 7.9 nM (TRPC6 currents)[3]
    In Vitro

    SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226 nM[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1]. SAR7334 (1 μM) has negligible effect on SOCE[2]. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SAR7334 Related Antibodies
    In Vivo

    SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    367.87

    Appearance

    Solid

    Formula

    C21H22ClN3O
    CAS No.
    SMILES

    N[C@@H](C1)CCCN1[C@@H]2CC3=CC=CC=C3[C@H]2OC4=C(Cl)C=C(C#N)C=C4
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 370 mg/mL (1005.79 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7184 mL 13.5918 mL 27.1835 mL
    5 mM 0.5437 mL 2.7184 mL 5.4367 mL
    10 mM 0.2718 mL 1.3592 mL 2.7184 mL
    *Please refer to the solubility information to select the appropriate solvent.
    Purity & Documentation

    Purity: 99.88%

    COA (255 KB) LCMS (97 KB)

    Handling Instructions (2659 KB)
    References
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    SAR7334 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    SAR73341333210-07-3SAR 7334SAR-7334TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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