1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. SAR7334

SAR7334 

Cat. No.: HY-15699 Purity: 99.91%
Handling Instructions

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

For research use only. We do not sell to patients.

SAR7334 Chemical Structure

SAR7334 Chemical Structure

CAS No. : 1333210-07-3

Size Price Stock Quantity
5 mg USD 336 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 780 In-stock
Estimated Time of Arrival: December 31
100 mg USD 960 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of SAR7334:

Top Publications Citing Use of Products

    SAR7334 purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Oct 3;9(10):1015.

    HK-2 cells are treated with different concentrations of SAR7334 for 12 h. Representative western blot images and the relative quantification of LC3-II are shown.

    View All TRP Channel Isoform Specific Products:

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

    IC50 & Target

    IC50: 7.9 nM (TRPC6 currents)[3]

    In Vitro

    SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226 nM[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1]. SAR7334 (1 μM) has negligible effect on SOCE[2]. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    367.87

    Formula

    C₂₁H₂₂ClN₃O

    CAS No.

    1333210-07-3

    SMILES

    N[[email protected]@H](C1)CCCN1[[email protected]@H]2CC3=CC=CC=C3[[email protected]]2OC4=C(Cl)C=C(C#N)C=C4

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 370 mg/mL (1005.79 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7184 mL 13.5918 mL 27.1835 mL
    5 mM 0.5437 mL 2.7184 mL 5.4367 mL
    10 mM 0.2718 mL 1.3592 mL 2.7184 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.91%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    SAR7334SAR 7334SAR-7334TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    SAR7334
    Cat. No.:
    HY-15699
    Quantity:
    MCE Japan Authorized Agent: