2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPC3/6-IN-1

TRPC3/6-IN-1 is a potent selectivity blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure.

For research use only. We do not sell to patients.

TRPC3/6-IN-1 Chemical Structure

TRPC3/6-IN-1 Chemical Structure

CAS No. : 736945-96-3

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TRPC3/6-IN-1 Related Antibodies

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Description

TRPC3/6-IN-1 is a potent selectivity blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure[1].

IC50 & Target

hTRPC3

1260 nM (IC50)

hTRPC6

500 nM (IC50)

In Vitro

TRPC3/6-IN-1 has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TRPC3/6-IN-1 Related Antibodies
In Vivo

TRPC3/6-IN-1 (compound 3) has good pharmacokinetic in rats[1].
Pharmacokinetic Parameters of TRPC3/6-IN-1 in rats [1].

Compd Dose(iv)(mg/kg) Cmax(iv)(ng/ml) CL(iv)(ml/min/kg) MRT(iv)(h) DNAUC(iv)(h•kg/L) %F
3 0.93 250 120 0.3 0.14 ~1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

365.45

Formula

C20H19N3O2S
CAS No.
SMILES

COC1=CC=C(NC2=NC(C(N3CCC4=C(C3)C=CC=C4)=O)=CS2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRPC3/6-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPC3/6-IN-1736945-96-3TRP ChannelTransient receptor potential channelsreceptor channelsTRPC3TRPC6anilino-thiazoleheart failureInhibitorinhibitorinhibit

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