2. Disease Areas
  3. Inflammation or Immune System Disease
  4. Allergy
  5. Allergic Rhinitis

Allergic Rhinitis

Allergic rhinitis is a common IgE-mediated type I hypersensitivity reaction triggered by exposure to airborne allergens such as pollen, pet dander, mold spores, dust mites, and cockroach droppings. It manifests as inflammation of the nasal mucosa, leading to symptoms including sneezing, nasal congestion, runny nose (rhinorrhea), itching in the nose and eyes, watery eyes, and sore throat. Symptoms typically occur within minutes of allergen exposure and can significantly impact sleep and daily functioning. The condition is classified as seasonal (e.g., hay fever due to pollen) or perennial (due to indoor allergens like dust mites and pet dander). Eosinophils contribute to mucosal swelling and hyperreactivity in the nasal airways. Management involves avoidance of triggers, pharmacological treatments such as antihistamines and nasal corticosteroids, nasal rinses, and immunotherapy (allergy shots) to reduce allergic sensitivity.

Allergic Rhinitis (10):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1589A
    Carbinoxamine maleate salt 3505-38-2 98.78%
    Carbinoxamine maleate salt is a blood-brain barrier-permeable histamine H1 receptor antagonist. Carbinoxamine maleate salt blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. Carbinoxamine maleate salt inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. Carbinoxamine maleate salt can be used in research on allergic rhinitis, influenza, etc.
    Carbinoxamine maleate salt
  • HY-18706
    trans-Tranilast 70806-55-2 99.63%
    trans-Tranilast (trans-MK-341) is an isomer of Tranilast (HY-B0195), and an anti-allergy agent used in studies of bronchial asthma, allergic rhinitis, and atopic dermatitis.
    trans-Tranilast
  • HY-12093A
    (R)-MMP408 1258003-93-8 99.91%
    (R)-MMP408 is an isomer of MMP408 (HY-12093). MMP408 is an orally active MMP-12 inhibitor (IC50=2.0 nM for hMMP-12) that effectively interferes with the epithelial-mesenchymal transition (EMT) process. MMP408 significantly upregulates the expression of E-cadherin in nasal epithelial cells, while inhibiting mesenchymal markers such as vimentin, α-smooth muscle actin and fibronectin, thereby reversing the EMT phenotype. MMP408 is used in studies of airway remodeling-related diseases, including chronic rhinosinusitis with nasal polyps, chronic obstructive pulmonary disease (COPD) and asthma.
    (R)-MMP408
  • HY-182736
    YM-344484 671205-14-4
    YM-344484 is an orally active dual antagonist of chemokine CCR3 receptor and histamine histamine H1 receptor. YM-344484 inhibits ligand-induced Ca2+ influx, chemotaxis of CCR3-expressing cells, histamine-induced Ca2+ influx, increased vascular permeability and eosinophil accumulation. YM-344484 suppresses vascular permeability and inhibits eosinophil infiltration in a mouse asthma model. YM-344484 can be used in research related to asthma, allergic rhinitis and atopic dermatitis.
    YM-344484
  • HY-182735
    BMS-570520 388101-58-4
    BMS-570520 is an orally bioavailable CCR3 antagonist with an IC50 of 1.9 nM against hCCR3 and an IC50 of 1300 nM against hCYP2D6. BMS-570520 inhibits CYP2D6, but shows low activity against off-target G protein-coupled receptors, biogenic amine transporters, and the hERG potassium channel. BMS-570520 regulates chemotaxis, calcium mobilization, and anti-inflammatory pathways. BMS-570520 can be used in research related to asthma, allergic rhinitis, and contact dermatitis.
    BMS-570520
  • HY-P992480
    VAK-694
    VAK-694 is a fully humanized anti-IL-4 monoclonal antibody. VAK-694 can be used for the research of seasonal allergic rhinitis.
    VAK-694
  • HY-P992440
    PF-06817024
    PF-06817024 is a high affinity, humanized antibody that binds IL-33. PF-06817024 binds to IL-33, prevents IL-33 from binding to receptor ST2, and inhibits downstream type 2 inflammatory responses. PF-06817024 can be used for the research of allergic diseases.
    PF-06817024
  • HY-182296
    SCH 79687 224585-45-9
    SCH 79687 is an orally active histamine H3 receptor antagonist, with a Ki of 1.9 nM in rats and 13 nM in guinea pigs. SCH 79687 acts as a competitive antagonist against (R)-α-methylhistamine. SCH 79687 attenuates the inhibitory effect of (R)-α-methylhistamine-induced sympathetic hypertensive responses in guinea pigs. When used in combination with H1 antagonists, SCH 79687 inhibits Compound 48/80 (HY-115768)-induced nasal congestion in cats. SCH 79687 can be used for the research of allergic rhinitis.
    SCH 79687
  • HY-182439
    AZD3778 485391-80-8
    AZD3778 (Compound 8) is an inhibitor of CCR3 and histamine H1 receptor (histamine H1 receptor), with IC50 values of 8.1 nM and 40 nM, respectively. AZD3778 inhibits the binding of eosinophil chemokines to CCR3, as well as the binding of histamine to histamine H1 receptor. AZD3778 exhibits anti-eosinophilic activity. AZD3778 alleviates symptoms associated with allergic rhinitis. AZD3778 can be used in research related to allergic rhinitis and asthma.
    AZD3778
  • HY-125137
    (R)-(-)-Chlorpheniramine maleate 23095-76-3
    (R)-(-)-Chlorpheniramine maleate is an enantiomer of Chlorpheniramine maleate (HY-B0286A). Chlorpheniramine maleate is a H1 antihistamines. (R)-(-)-Chlorpheniramine maleate can be used for allergic diseases such as rhinitis and urticaria research.
    (R)-(-)-Chlorpheniramine maleate