Ovalbumin, low endotoxin
Based on 1 Customer Validation
Ovalbumin, low endotoxin (OVA, low endotoxin), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues. Ovalbumin, a low endotoxin, can be used to establish an asthma model.
For research use only. We do not sell to patients.
- CAS No.: 9006-59-1
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Induction of Asthma[2][3].
Administration: 100 μg • intraperitoneal injection • on days 0, 7, and 14 • then challenged by inhaled Ovalbumin (OVA) (100 µg in 50 µL PBS per mouse) on Days 22, 24, and 26.
Rat: SD rats • male • four-week-old
Administration: 20 mg/kg • intraperitoneal injection • every other day for a total of 7 injections • After 16 days, the rats received a daily dose of 20 mg/kg OVA through ultrasonic atomizing inhalation for 7 days. Seven days after atomizing inhalation of OVA, allergic rhinitis (AR) responses are examined by dropping 50 μL of 2 % OVA into the nasal cavity of rats.
1) The BALB/c mice are sacrificed 24 h after the last OVA challenge.
Histological analysis: Induces a significant increase in the total number of cells infiltrating the peribronchial and perivascular areas of the lung tissues, predominantly eosinophils.
The lung tissues of OVA-sensitized rats showed significant inflammatory cell infiltration and goblet cell hyperplasia.
Biochemical markers: The content of IL-17A in the serum, NALF, BALF, and lung tissue homogenate of OVA-sensitized rats was increased.
Immunohistochemistry analysis: The expression of IL-22RA1 and IL-10RB in the lung tissues is significantly increased.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9006-59-1
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Appearance Solid
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Color White to off-white
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SMILES
[Ovalbumin, low endotoxin]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Heejae Han, et al. Toxic and adjuvant effects of silica nanoparticles on ovalbumin-induced allergic airway inflammation in mice. Respir Res. 2016 May 18;17(1):60. [Content Brief]
[2]. Wang J, et al. Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model. BMC Pulm Med. 2021 Nov 26;21(1):385. [Content Brief]
[3]. He Y, et al. Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD. Phytomedicine. 2025 Apr;139:156508. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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