Ovalbumin, low endotoxin

Cat. No.: HY-W250978A: Data Sheet
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Ovalbumin, low endotoxin (OVA, low endotoxin), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues. Ovalbumin, a low endotoxin, can be used to establish an asthma model.

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Ovalbumin, low endotoxin Chemical Structure

CAS No. : 9006-59-1

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Description	Ovalbumin, low endotoxin (OVA, low endotoxin), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues^[1]. Ovalbumin, a low endotoxin, can be used to establish an asthma model^[2]^[3].
In Vivo	Note: Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment. Induction of Asthma^[2]^[3]. Induction of NAFLD^[1] Background Through artificial sensitization and challenge, the Th2 immune response and subsequent inflammatory process of human allergic asthma are simulated in mice (or other animals, such as rats). Specific Modeling Methods Mice: BALB/c mice • female • 6-8-week-old Administration: 100 μg • intraperitoneal injection • on days 0, 7, and 14 • then challenged by inhaled Ovalbumin (OVA) (100 µg in 50 µL PBS per mouse) on Days 22, 24, and 26. Rat: SD rats • male • four-week-old Administration: 20 mg/kg • intraperitoneal injection • every other day for a total of 7 injections • After 16 days, the rats received a daily dose of 20 mg/kg OVA through ultrasonic atomizing inhalation for 7 days. Seven days after atomizing inhalation of OVA, allergic rhinitis (AR) responses are examined by dropping 50 μL of 2 % OVA into the nasal cavity of rats. Note Tips: 1) The BALB/c mice are sacrificed 24 h after the last OVA challenge. Modeling Indicators Behavioral analysis: OVA sensitization is found to cause rats to exhibit nose rubbing and sneezing frequently. OVA-specific IgE and IgG1 levels are higher in modeled rats.Airway hyperresponsiveness: The Respiratory system resistance (Rrs) and Elastance (Ers) values are significantly elevated in OVA-induced mice, the Compliance (Crs) values are dramatically decreased. Histological analysis: Induces a significant increase in the total number of cells infiltrating the peribronchial and perivascular areas of the lung tissues, predominantly eosinophils. The lung tissues of OVA-sensitized rats showed significant inflammatory cell infiltration and goblet cell hyperplasia. Biochemical markers: The content of IL-17A in the serum, NALF, BALF, and lung tissue homogenate of OVA-sensitized rats was increased. Immunohistochemistry analysis: The expression of IL-22RA1 and IL-10RB in the lung tissues is significantly increased. Correlated Product(s): Aluminum Hydroxide (HY-B1521) MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.	9006-59-1
Appearance	Solid
Color	White to off-white
SMILES	[Ovalbumin, low endotoxin]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Select Batch: Data Sheet (270 KB) SDS (251 KB) COA (231 KB) Others (101 KB) Handling Instructions (2659 KB)
References	[1]. Heejae Han, et al. Toxic and adjuvant effects of silica nanoparticles on ovalbumin-induced allergic airway inflammation in mice. Respir Res. 2016 May 18;17(1):60. [Content Brief] [2]. Wang J, et al. Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model. BMC Pulm Med. 2021 Nov 26;21(1):385. [Content Brief] [3]. He Y, et al. Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD. Phytomedicine. 2025 Apr;139:156508. [Content Brief]