Human serum albumin
Based on 5 publication(s) in Google Scholar
Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO−) in the vascular wall, contributing to the reduction of blood pressure.
This product is recombinant Human Serum Albumin expressed in a microbial expression system.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 70024-90-7
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Human serum albumin
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Customer Validation & Images
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Bio/Physico-chemical Assay
Biological Activity
This product is recombinant Human Serum Albumin expressed in a microbial expression system.
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iNOS |
HAS (5 μM, 0-90 minutes) can bind with Glycerol Monolaurate (GML), with a Kd value of 1.4 μM. HSA can prevent the ability of GML to inhibit human T cells and protect the function of T cells[3].
HSA (0.01, 0.05, 0.1 μM, 0-24 h) alleviates the GML-induced phosphorylation of AKT at threonine 308 and serine 473 residues as well as the formation of LAT, PLC-γ1, and AKT microclusters, and restores the production of IFN-γ, IL-2, IL-10, and TNF-α in GML-treated cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Activate peripheral blood T cells
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Concentration:0.05 μM
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Incubation Time:0, 2, 5, 15 min
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Result:Affected the ability of GML to inhibit AKT phosphorylation.
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Cell Line:Activate peripheral blood T cells
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Concentration:0.1, 0.05, 0.005 μM
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Incubation Time:24h
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Result:Restored the production of IFN-γ, IL-2, IL-10, and TNF-α in GML treated cells.
Human serum albumin (10 ml/kg; Intravenous injection; Once at 1 hour and once at 5 hours; twice) in a Male Swiss mouse model completely prevented endotoxin-induced reduced vascular response to phenol catecholamines, electromyotonia, and endothelial dysfunction, and reduced inflammatory processes leading to oxidative and nitrite stress and reduced vascular reactivity[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss mouse models[4]
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Dosage:10 ml/kg; Once at 1 hour and once at 5 hours; twice
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Administration:HSA: Intravenous injection; LPS: Intraperitoneal injection (i.p.), 50 mg/kg
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Result:Prevented LPS-induced tissue NO overproduction and increased iNOS expression.
Was effective in reducing LPS-induced oxidative stress.
Alleviated this LPS-induced oxidative stress and inhibited the formation of peroxynitrite (ONOO−).
Reduced LPS-induced upregulation of NF-κB.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 70024-90-7
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Appearance Solid
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Color White to light yellow
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SMILES
[Human serum albumin]
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Synonyms
HSA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
RGD-HSA-TAC nanoparticles targeted delivery of tacrolimus and attenuation of podocyte injury in diabetic kidney disease. [Abstract]2025 Feb 4;23(1):81. PMID: 39905421 -
Cell Rep
Mitochondrial nucleoid condensates drive peripheral fission through high membrane curvature. [Abstract]2023 Nov 23;42(12):113472. PMID: 37999975
Human serum albumin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Nov 23;42(12):113472. [Abstract]
The fluorescent response of mtGLP to cholesterol, triglyceride and Human serum albumin (HSA). Emission spectra of mtGLP to DOPC (40 μg/mL) in the presence of HSA (80 μg/mL), cholesterol(80μg/mL) and triglyceride (80 μg/mL) in 10.0 mM Tris-HCl buffer (pH 7.4,100.0 mMK+) with excitationatλex=405 nm.
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Anal Chem
Rational Design of Nonmetal Material Self-Mediated Electron Transfer-Based Electrochemiluminescence Sensing Platform and Its Application. [Abstract]2025 Nov 25;97(46):25803-25809. PMID: 41233168 -
Biomed Mater
Multi-channel microfluidic chip with bilateral stripe for reconstruction of tissue barrier models in vitro. [Abstract]2026 Jun 4;21(3). PMID: 42173142 -
Solvent & Solubility
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med. 2018 Jun;52:8-12. [Content Brief]
[2]. Fanali G, et al. Human serum albumin: from bench to bedside. Mol Aspects Med. 2012 Jun;33(3):209-90. [Content Brief]
[3]. Zhang MS, et al. Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function. PLoS One. 2016;11(10):e0165083. Published 2016 Oct 20. [Content Brief]
[4]. Meziani F, et al. Human serum albumin improves arterial dysfunction during early resuscitation in mouse endotoxic model via reduced oxidative and nitrosative stresses. Am J Pathol. 2007;171(6):1753-1761. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Human serum albumin Related Classifications
HY-P1956 Related Classifications
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