1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Hyaluronic acid

Hyaluronic acid (Synonyms: Hyaluronate)

Cat. No.: HY-B0633A
Handling Instructions

Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

For research use only. We do not sell to patients.

Hyaluronic acid Chemical Structure

Hyaluronic acid Chemical Structure

CAS No. : 9004-61-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Hyaluronic acid:

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Description

Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Hyaluronic acid (HA) is widely used in aesthetic medicine due to its binding ability with a large number of water molecules. It improves tissue hydration and their resistance to mechanical damage. HA plays an important role in wound healing, ovulation, fertilization, signal transduction, and tumor physiology. HA is used in joint diseases such as osteoarthritis or rheumatoid arthritis. HA of a high molecular mass reduces the chemotaxis and migration of inflammatory cells which acts as a good barrier to the inflammatory process and protects against the effects of free radicals. HA is used in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicate its role in tumor markers, liver diseases, and in pharmaceuticals[1]. Hyaluronan plays an important role in cancer growth and metastasis. HA and HA fragment-tumor cell interaction could activate the downstream signaling pathways, promoting cell proliferation, adhesion, migration and invasion, and inducing angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like property, and chemoradioresistance in digestive cancers[2].

In Vivo

The impact of applied intra-articular HA has been proven in many studies in animals. Studies on HA have shown that it promotes the synthesis of cartilage matrix, prevents its degradation, reduces inflammation, stimulates the synthesis of endogenous HA, and improves the resilience and moisture of cartilage [1]. High molecular size HA preparations, applied topically, promote healing of fresh skin wounds. They also promote the healing of venous leg ulcers and are useful in the management of chronic wounds[3].

Clinical Trial
Molecular Weight

379.32 (monomer)

Formula

(C₁₄H₂₁NO₁₁)n

CAS No.

9004-61-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 6.8 mg/mL (Need ultrasonic)

References
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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Hyaluronic acidHyaluronateEndogenous MetaboliteInhibitorinhibitorinhibit

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