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    Endogenous Metabolite
  3. Heparan Sulfate

Heparan Sulfate 

Cat. No.: HY-101916
Handling Instructions

Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

For research use only. We do not sell to patients.

Heparan Sulfate Chemical Structure

Heparan Sulfate Chemical Structure

CAS No. : 9050-30-0

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5 mg USD 528 In-stock
Estimated Time of Arrival: December 31
10 mg USD 924 In-stock
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25 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
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Based on 6 publication(s) in Google Scholar

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Description

Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Heparan sulfate is a linear polysaccharide and belongs to the family of glycosaminoglycans. Heparan sulfate is composed of glucuronic acid (GlcA) and iduronic acid (IdoA) residues as well as N-acetyl glucosamines (GlcNAc) with various sulfation modifications, and is typically 50-200 disaccharides in length. Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates. Heparan sulfate chains regulate developmental signaling by acting as co-factors through a variety of mechanisms that include but are not limited to maintenance of morphogen gradients and co-receptor functions[1]. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions[2]. Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Digestion of heparan sulfate impairs context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, heparan sulfate maintains neuronal excitability and, as a consequence, support synaptic plasticity and learning[4]. FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

593.47 (monomer)

Formula

C₁₂H₁₉NO₂₀S₃ (monomer)

CAS No.

9050-30-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 47.1 mg/mL (Need ultrasonic and warming)

References
Animal Administration
[5]

Rats: Sprague-Dawley male rats 3-4 months old receive aspiration of a small segment of the motor-sensory cortex in both hemispheres. Groups of rats (n=5) receive a piece of Gelfoam embedded with human recombinant FGF-2, heparan sulfate (10 kg/mL; sodium salt, bovine kidney) dissolved in PBS, or both, in the right hemisphere. The wound cavity of the left hemisphere receives a piece of Gelfoam embedded with saline[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

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Keywords:

HeparanFGFRWntEndogenous MetaboliteFibroblast growth factor receptorInhibitorinhibitorinhibit

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Heparan Sulfate
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HY-101916
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