2. Metabolic Enzyme/Protease Anti-infection PI3K/Akt/mTOR
  3. Endogenous Metabolite Bacterial PI3K Akt
  4. Hyaluronic acid sodium

Hyaluronic acid sodium  (Synonyms: Sodium hyaluronate)

Cat. No.: HY-B0633 Purity: 98.0%
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Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). Hyaluronic acid sodium is synthesized at the plasma membrane. Increased hyaluronic acid sodium levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid sodium participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid sodium activates the PI3K-Akt signaling. Hyaluronic acid sodium acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid sodium can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid sodium can be studied in joint diseases, wound healing and cancer.

For research use only. We do not sell to patients.

CAS No. : 9067-32-7

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Based on 18 publication(s) in Google Scholar

Other Forms of Hyaluronic acid sodium:

Hyaluronic acid sodium Related Antibodies

Top Publications Citing Use of Products

    Hyaluronic acid sodium purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 Oct;42(44):3221-3235.  [Abstract]

    4T1 cells mixed with exogenous Hyaluronic acid (HA, 500 μg) were subcutaneously inoculated into BALB/c mice, the mice were sacrificed on the eighth day after tumor graft. Representative immunofluorescent images of HA (green) and Hoechst33342 (blue) in tumors (left, scale bar, 100 μm), and statistic result of the MFI of HA (right), n = 4. P values were calculated by two-tailed unpaired t tests. E-F, The MSCs supernatant react with increasing dose of DOX. The results showed that exogenous HA was effectively converted into increased intratumoral HA content when assayed on the eighth day after tumor implantation.

    Hyaluronic acid sodium purchased from MedChemExpress. Usage Cited in: J Chem Neuroanat. 2021 Nov:117:101996.

    Photomicrograph of the visual cortex in section following hyaluronic acid injection and caffeine treatment. C (control group) revealed a normal neuronal cells distribution pattern with distinct nuclei; HA (Hyaluronic acid group; 25 μL/kg; single injection at the unilateral corneoscleral limbus) revealed pyknotic and scanty distribution of neuronal cells. PHA (intervention group) revealed histological alteration when compared to control group. CAF (caffeine group; 20 mg/kg; i.p.; once daily for 7 days) revealed scantily distribution of normal neuronal cells. Stained with H&E, (Scale bar = 51 μm).

    Hyaluronic acid sodium purchased from MedChemExpress. Usage Cited in: J Chem Neuroanat. 2021 Nov:117:101996.

    Photomicrograph showing TNF-α in a rat glaucomatous visual cortex. C represents the control group; HA (Hyaluronic acid; 25 μL/kg; single injection at the unilateral corneoscleral limbus) represent the hyaluronic acid group; PHA represents the intervention group; CAF represent the caffeine group. The expressions of TNF-α, and the damaged cells were characterized by a deep brown precipitates, round and shrunken morphology. (Scale bar = 51 μm).

    Hyaluronic acid sodium purchased from MedChemExpress. Usage Cited in: J Chem Neuroanat. 2021 Nov:117:101996.

    Effect of Caffeine on the tumour necrosis factor in the LGB and visual cortex of HA (25 μL/kg; single injection at the unilateral corneoscleral limbus)-induced rat. A): Tunel assay immunoreactivity in the primary visual cortex. B): Tunel assay immunoreactivity in the Lateral geniculate nucleus (LGN). Data represented as mean ± S.E.M. (n = 4). C = Control, HA= Hyaluronic acid, PHA = Post treatment group, CAF = Caffeine.

    Hyaluronic acid sodium purchased from MedChemExpress. Usage Cited in: J Chem Neuroanat. 2021 Nov:117:101996.

    Tonopen measurements of IOP in rats with hyaluronic acid injection and caffeine treatment. The elevated IOP was observed in rats injected with hyaluronic acid compared to the control and caffeine group. The distinction between the control, CAF and HA (Hyaluronic acid group; 25 μL/kg; single injection at the unilateral corneoscleral limbus) group was statistically significant after 8 days of HA injection. Control (C); hyaluronic acid (HA); Post hyaluronic acid (PHA); Caffeine (CAF); Intraocular pressure (IOP) *P < 0.05 (P value = 0.0001).

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    Description

    Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). Hyaluronic acid sodium is synthesized at the plasma membrane. Increased hyaluronic acid sodium levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid sodium participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid sodium activates the PI3K-Akt signaling. Hyaluronic acid sodium acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid sodium can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid sodium can be studied in joint diseases, wound healing and cancer[1][2][3][4][5].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Hyaluronic acid (HA) is widely used in aesthetic medicine due to its binding ability with a large number of water molecules. It improves tissue hydration and their resistance to mechanical damage. HA plays an important role in wound healing, ovulation, fertilization, signal transduction, and tumor physiology. HA is used in joint diseases such as osteoarthritis or rheumatoid arthritis. HA of a high molecular mass reduces the chemotaxis and migration of inflammatory cells which acts as a good barrier to the inflammatory process and protects against the effects of free radicals. HA is used in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicate its role in tumor markers, liver diseases, and in pharmaceuticals[1]. Hyaluronan plays an important role in cancer growth and metastasis. HA and HA fragment-tumor cell interaction could activate the downstream signaling pathways, promoting cell proliferation, adhesion, migration and invasion, and inducing angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like property, and chemoradioresistance in digestive cancers[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Hyaluronic acid sodium Related Antibodies
    In Vivo

    The impact of applied intra-articular HA has been proven in many studies in animals. Studies on HA have shown that it promotes the synthesis of cartilage matrix, prevents its degradation, reduces inflammation, stimulates the synthesis of endogenous HA, and improves the resilience and moisture of cartilage[1]. High molecular size HA preparations, applied topically, promote healing of fresh skin wounds. They also promote the healing of venous leg ulcers and are useful in the management of chronic wounds[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    1500 (kDa)

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CO[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O[C@H]2[C@@H]([C@H]([C@@H](O[C@H]2C(O[Na])=O)OC)O)O)[C@@H]1NC(C)=O.[n]
    Structure Classification
    Initial Source

    almost all biological fluids and tissues
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 3.33 mg/mL (Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 33.33 mg/mL; Clear solution; Need ultrasonic

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    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.0%

    SDS (393 KB)

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    Hyaluronic acid sodium Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Hyaluronic acid9067-32-7Sodium hyaluronateEndogenous MetaboliteBacterialPI3KAktPhosphoinositide 3-kinasePKBProtein kinase BInhibitorinhibitorinhibit

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