2. Immunology/Inflammation
  3. Interleukin Related
  4. PF-06817024

PF-06817024 is a high affinity, humanized antibody that binds IL-33. PF-06817024 binds to IL-33, prevents IL-33 from binding to receptor ST2, and inhibits downstream type 2 inflammatory responses. PF-06817024 can be used for the research of allergic diseases.

For research use only. We do not sell to patients.

PF-06817024

PF-06817024 Chemical Structure

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PF-06817024 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

PF-06817024 is a high affinity, humanized antibody that binds IL-33. PF-06817024 binds to IL-33, prevents IL-33 from binding to receptor ST2, and inhibits downstream type 2 inflammatory responses. PF-06817024 can be used for the research of allergic diseases[1][2].

Species Reactivity

Human
IC50 & Target[1]

ST2

 

In Vitro

PF-06817024 binds with high, specific affinity to human and cynomolgus monkey IL-33 variants[1].
PF-06817024 potently neutralizes IL-33 activity in human mast cells with an IC50 of 64 pM[1].
PF-06817024 neutralizes IL-33 activity in human whole blood, human peripheral blood mononuclear cells, and IL-33 receptor-overexpressing recombinant cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-06817024 Related Antibodies
Parmacokinetics
Species Dose Route CL Vss T1/2
Cynomolgus Monkey[1] 300 mg/kg i.v. 0.058 mL/h/kg 56 mL/kg 432 h
Gene ID

90865  [NCBI]

Accession
Target

IL-33
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-06817024 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-06817024PF06817024PF 06817024Interleukin RelatedILST2type 2 inflammatory responsesinterleukin-33human peripheral blood mononuclear cellsIL-33cynomolgus monkeymoderate-to-severe atopic dermatitishuman mast cellseosinophilchronic rhinosinusitis with nasal polypsInhibitorinhibitorinhibit

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PF-06817024
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