IL33 - interleukin 33 Gene

Also Known as DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 90865

About IL33

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:6,215,149-6,257,983 (from NCBI)

This gene has 6 transcripts (splice variants) and 89 orthologues. Ubiquitous expression in urinary bladder (RPKM 34.7), lung (RPKM 27.3) and 23 other tissues.

Summary

The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

IL33 Products (9)

mRNA	Protein	Name
NM_001199640.2	NP_001186569.1	interleukin-33 isoform b
NM_001199641.2	NP_001186570.1	interleukin-33 isoform c
NM_001314044.2	NP_001300973.1	interleukin-33 isoform a precursor
NM_001314045.2	NP_001300974.1	interleukin-33 isoform a precursor
NM_001314046.2	NP_001300975.1	interleukin-33 isoform d
NM_001314047.2	NP_001300976.1	interleukin-33 isoform d
NM_001314048.2	NP_001300977.1	interleukin-33 isoform e
NM_001353802.2	NP_001340731.1	interleukin-33 isoform f
NM_033439.4	NP_254274.1	interleukin-33 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	19841166	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16286016	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17185418	GOA
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	19841166	GOA
involved in positive regulation of macrophage activation	IDA IDA: Inferred from direct assay	19841166	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22215666	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	27830702	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18787100	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL33 Protein Structure

IL33

0
100
200
270 a.a.

Protein Preferred Names	Protein Names
interleukin-33	DVS27-related protein

IL33 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL33	O95760	H2AC11	Homo sapiens	P0C0S8	Pull Down	18688256

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL33 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7041	IL-33 Protein, Human	O95760-1 (S112-T270)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70475	IL-33 Protein, Human (His)	O95760-1 (S112-T270)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70475AF	Animal-Free IL-33 Protein, Human (His)	O95760-1 (S112-T270)	≥ 95%, as determined by reducing SDS-PAGE.

IL33 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811333	IL-33 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P89813	IL-33 Antibody (YA9157)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Autoimmune Pancreatitis	Lymphoplasmocytic Sclerosing Pancreatitis Aip
Granulomatous Mastitis	Idiopathic Granulomatous Mastitis
Loeffler Syndrome	Loeffler'S Pneumonia Loffler'S Syndrome Simple Pulmonary Eosinophilia
Esophagitis	Acute Esophagitis
Respiratory Allergy	Airway Allergy
Chronic Asthma
Conjunctivitis	Madras Eye Adenoviral Conjunctivitis Acute Adenoviral Follicular Conjunctivitis Inclusion Conjunctivitis Of The Adult Swimming-Pool Conjunctivitis Inflammation Of Conjunctiva Ophthalmia Acute Conjunctivitis Eye Catarrh Catarrhal Ophthalmia Koch-Weeks Conjunctivitis
Schistosomiasis	Katayama Fever Bilharzia Bilharziasis Schistosomiasis Mansoni Blood Fluke Schistosoma Mansoni Infection Snail Fever Acute Schistosomiasis Schistosomiasis Manson Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis] Intestinal Schistosomiasis Nos Intestinal Schistosomiasis Egyptian Splenomegaly Bilharziasis Of Intestine Schistosomal Dysentery Schistosomiasis Of Colon Asiatic Schistosomiasis Eastern Schistosomiasis Schistosoma Japonicum Infection Schistosomiasis Japonicum Katayama Disease Katayama Syndrome Oriental Schistosomiasis
Nasal Cavity Disease	Disorder Of Nasal Cavity
Rhinitis	Runny Nose
T2-Low Asthma	Type 2 Low Endotype
Rosacea	Erythematotelangiectatic Rosacea Papulopustular Rosacea Phymatous Rosacea Acne Roscea Acne, Erythematosa Granulomatous Rosacea Ocular Rosacea Acne Rosacea Hypertrophic Rosacea
T2-High Asthma	Type 2 High Endotype
Nose Disease	Nose Diseases Disorder Of The Nose Nasal Disorder Abnormality Of The Nose
Bronchiolitis
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Acute Asthma
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Intrinsic Asthma	Non-Atopic Asthma
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Occupational Asthma
Environmental Induced Asthma	Irritant Asthma
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Achalasia	Cardiospasm Achalasia Of Cardia Esophageal Achalasia Hypertensive Lower Esophageal Sphincter Idiopathic Achalasia Achalasia Cardia Idiopathic Achalasia Of Esophagus Primary Achalasia Achalasia Of Esophagus Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter Aperistalsis Of The Oesophagus Achalasia Of Oesophagus Oesophageal Achalasia Achalasia Nos Cardia Spasm Cardia Achalasia Oesophageal Cardiospasm Oesophagus Achalasia Reflex Cardiospasm
Legume Allergy	Fabaceae Allergy
Fruit Allergy	Allergy To Fruit
Common Cold	Acute Coryza Acute Nasopharyngitis Acute Rhinitis Acute Viral Rhinopharyngitis Nasopharyngitis - Acute Nasopharyngitis, Acute Rhino-Sinusitis Rhinosinusitis Common Colds Acute Infective Rhinitis Cold Coryza Head Cold Infective Nasopharyngitis Rhinopharyngitis Acute Nasal Catarrh Infective Rhinitis Acute Nasopharyngeal Catarrh Infective Nasopharyngitis Nos Nasopharyngitis Nos Epipharyngitis Mucositis Nos Inflammatory Disease Of Mucous Membrane Mucosal Inflammation
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Chronic Conjunctivitis
Contact Dermatitis	Contact Dermatitis/Eczema Contact Eczema Dermatitis Venenata Dermatitis, Venenata Dermatitis Contact Dermatitis, Contact
Chronic Ethmoiditis	Chronic Ethmoidal Sinusitis Chronic Ethmoid Sinusitis Ethmoidal Sinusitis - Chronic
Peanut Allergy	Allergy To Peanuts Peanut Allergic Reaction Allergies Peanut Peanut Hypersensitivity
Allergic Conjunctivitis	Conjunctivitis Allergic Conjunctivitis, Allergic Allergen-Induced Conjunctivitis Seasonal Allergic Conjunctivitis Perennial Allergic Conjunctivitis Spring Conjunctivitis Acute Allergic Conjunctivitis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Near-Fatal Asthma
Childhood-Onset Asthma	Childhood Asthma Asthma Childhood
Chronic Rhinitis	Rhinitis - Chronic Chronic Rhinitis Nos Rhinitis Rhinitis Nos
Thunderstorm Triggered Asthma	Thunderstorm Asthma Thunderstorm Related Asthma
Thiopental Allergy	Penthiobarbital Allergy Pentothiobarbital Allergy
Goat Milk Allergy	Capra Hircus Milk Allergy
Esophagitis, Eosinophilic, 1	Eosinophilic Esophagitis EOE1 Esophagitis, Eosinophilic Ee
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Allergic Contact Dermatitis	Dermatitis, Allergic Contact Contact Dermatitis, Allergic Dermatitis Allergic Contact Allergic Contact Eczema Acd - [Allergic Contact Dermatitis] Allergic Contact Dermatitis, Unspecified Cause Allergic Dermatitis Allergic Eczema Allergy Dermatitis Allergy Eczema Allergic Contact Eczema Due To Clothing Or Footwear Perfume Allergic Contact Dermatitis Allergic Contact Dermatitis Due To Cosmetics Allergic Contact Eczema Due To Cosmetics Or Fragrances Allergic Contact Eczema Due To Dental Materials Allergic Contact Eczema Due To Food Flavours Or Additives Allergic Contact Eczema Due To Hairdressing Products Allergic Contact Eczema Due To Metals Or Metal Salts Allergic Contact Eczema Due To Proteins Allergic Contact Eczema Due To Plastics Or Resin Systems Allergic Contact Eczema Due To Preservatives Or Biocides Allergic Contact Eczema Due To Rubber Chemicals Rubber Dermatitis Allergic Contact Eczema Due To Systemic Medicaments Allergic Contact Eczema Due To Topical Medicaments Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Pneumothorax, Primary Spontaneous	Primary Spontaneous Pneumothorax Spontaneous Pneumothorax Familial Spontaneous Pneumothorax PSP Pneumothorax
Intermittent Asthma
Food Allergy	Food Hypersensitivity Food Allergies Allergy Food Food Allergen-Induced Hypersensitivity
Conjunctival Disease	Conjunctival Diseases Conjunctival Disorder
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Leukocyte Disease	Leukocyte Disorders
Dermatitis, Atopic, 5	ATOD5 Atopic Dermatitis 5 Dermatitis, Atopic, Susceptibility To, 5 Dermatitis, Atopic 5
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Integumentary System Disease
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Chronic Congestive Splenomegaly
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99444	Astegolimab	Inhibitor	99.00%	Phase 3
HY-P99673	Itepekimab	Inhibitor	99.496%	Phase 3
HY-P99018	Etokimab	Inhibitor	99.90%	Phase 2
HY-P991633	TQC2938	Inhibitor	/	Phase 2
HY-P991267	CAN10	Inhibitor	95.04%	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2729	Subtilisin	Activator	/	Unkown
HY-114354	BODIPY FL alkyne		98.60%	Unkown
HY-W060417	iST2-1	Inhibitor	99.58%	Unkown
HY-168532	ST2-IN-1	Inhibitor	99.05%	Unkown
HY-163140	BODIPY-phenyl-amide-alkyne		/	Unkown
HY-178144	FPR2 agonist 5		/	Unkown
HY-182370	TKP-5	Degrader	/	Unkown
HY-182693	CPL302-253	Inhibitor	/	Unkown
HY-404647	FK3453	Inhibitor	99.98%	Unkown
HY-RS06757	IL33 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174607	Human IL33 mRNA		/	Unkown
HY-RS16666	Il33 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23101	Il33 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99729	Melrilimab	Inhibitor	96.07%	Unkown
HY-P990669	Torudokimab	Inhibitor	99.72%	Unkown
HY-P992440	PF-06817024	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IL33	VGNC	VGNC:73606
Canis familiaris	IL33	VGNC	VGNC:41982
Bos taurus	IL33	VGNC	VGNC:30155
Mus musculus	IL33	MGD	MGI:1924375
Felis catus	IL33	VGNC	VGNC:62912
Rattus norvegicus	IL33	RGD	RGD:1311155
Others	IL33	NCBI