1. Immunology/Inflammation NF-κB
  2. Interleukin Related NF-κB
  3. Itepekimab

Itepekimab  (Synonyms: REGN-3500; SAR-440340)

Cat. No.: HY-P99673 Purity: ≥95.0%
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Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD).

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Itepekimab Chemical Structure

Itepekimab Chemical Structure

CAS No. : 2226742-52-3

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Description

Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD)[1][2][3][4].

In Vitro

Itepekimab can bind IL-33 with high affinity and prevent the binding of ST2 D3 domain to IL-33, thus preventing the formation of IL-33/ST2/IL-1RAcP signaling complex and blocking the production of airway inflammatory mediator[4].
Itepekimab also binds with subnanomolar affinity to different IL-33 cleavage variants, blocks NF-kB signaling in reporter cell lines, and prevents cytokine release from human peripheral blood mononuclear cell[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Itepekimab ameliorates type 1 and type 2 lung inflammation and prevents characteristic lung remodeling in mice. Itepekimab prevents IL-33/ST2/IL-1RAcP complex formation and reconstitutes ciliated cells in a mouse model of persistent airway inflammation[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Itepekimab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

References
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Itepekimab Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Itepekimab
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