2226742-52-3
2226742-52-3
Chemical Structure
Itepekimab
Synonym(s): REGN-3500; SAR-440340
- CAS No.: 2226742-52-3
- Formula:N/A
- Molecular Weight:(144.64 kDa)
SMILES: [Itepekimab]
Biological Activity: Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD)[1][2][3][4].
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Itepekimab | 99.496% | Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD). | ||||||||||||||||||||
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References
- [1]. Wechsler ME, et al. Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. N Engl J Med. 2021 Oct 28;385(18):1656-1668. [Content Brief]
- [2]. Rabe KF, et al. Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial. Lancet Respir Med. 2021 Nov;9(11):1288-1298. [Content Brief]
- [3]. Kosloski MP, et al. Pharmacokinetics and pharmacodynamics of itepekimab in healthy adults and patients with asthma: Phase I first-in-human and first-in-patient trials. Clin Transl Sci. 2022 Feb;15(2):384-395. [Content Brief]
- [4]. Asrat S, et al. Itepekimab Binds to IL-33 With High Affinity, Prevents the Formation of IL-33/ST2/IL-1RAcP Signaling Complex and Blocks Mediators of Airway Inflammation[M]//C13. CYTOKINES: CYTOKINES IN THE AIRWAYS. American Thoracic Society, 2023: A4478-A4478.
Keywords
