2. Immunology/Inflammation Apoptosis NF-κB
  3. Interleukin Related MDM-2/p53 NF-κB
  4. Astegolimab

Astegolimab  (Synonyms: MSTT 1041A; RG 6149)

Cat. No.: HY-P99444 Purity: 99.00%
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Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research.

For research use only. We do not sell to patients.

CAS No. : 2173054-79-8

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Customer Review

Based on 2 publication(s) in Google Scholar

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Astegolimab Related Antibodies

Top Publications Citing Use of Products

    Astegolimab purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Apr;48(2):487-504.  [Abstract]

    Astegolimab (IL33-IN). ELISA was used to detect the concentrations of mouse bone marrow-derived ribonuclease (BMDN) and elastase in HL-60 cell supernatant.

    Astegolimab purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Apr;48(2):487-504.  [Abstract]

    Astegolimab (IL33-IN). Western blot analysis of molecules associated with NET formation in mouse bone marrow-derived macrophages (BMDN).

    View All Interleukin Related Isoform Specific Products:

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    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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    Description

    Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research[1][2][3].

    Isotype

    Human IgG2 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target[1]

    ST2

     

    In Vitro

    Astegolimab could block the effect of CM-induced neutrophil extracellular trap (NET) formation in HL-60 cells[2].
    Astegolimab (10 μM) blocks the effect of exogenous IL33 on cardiomyocyte (AC16) senescence[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Astegolimab Related Antibodies

    Western Blot Analysis[3]

    Cell Line: AC16 cells treated with IL33
    Concentration: 10 μM
    Incubation Time:
    Result: Reduced p53 expression.
    Mitigated IL33-upregulated SASP factors such as IL1α, IL6 and MCP1.
    Mitigated IL33-increased p-p65/p65 ratio.
    Clinical Trial
    Gene ID

    9173  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    144.98 kDa

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Astegolimab]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG2 kappa
    Biological Activity
    • Immobilized ST2/IL1RL1 Protein, Human can bind Astegolimab. The EC50 for this effect is 28.29 ng/mL.
    • Loaded ST2/IL1RL1 Protein, Human (310a.a, HEK293, His, HY-P70615) on AHC2 biosensor, can bind Astegolimab with an affinity constant of 2.022E-10 M as determined in BLI assay.
    Purity & Documentation

    Purity: 99.00%

    SDS (252 KB)

    COA (232 KB) SDS-PAGE (110 KB) SEC-HPLC (465 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Astegolimab Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Astegolimab2173054-79-8MSTT 1041A RG 6149RG6149RG 6149RG-6149Interleukin RelatedMDM-2/p53NF-κBILNuclear factor-κBNuclear factor-kappaBIgG2monoclonal antibodyIL-33ST2chronic obstructive pulmonary diseaseCOPDInhibitorinhibitorinhibit

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