AZD3778

Cat. No.: HY-182439: Data Sheet Handling Instructions
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AZD3778 (Compound 8) is an inhibitor of CCR3 and histamine H1 receptor (histamine H1 receptor), with IC₅₀ values of 8.1 nM and 40 nM, respectively. AZD3778 inhibits the binding of eosinophil chemokines to CCR3, as well as the binding of histamine to histamine H1 receptor. AZD3778 exhibits anti-eosinophilic activity. AZD3778 alleviates symptoms associated with allergic rhinitis. AZD3778 can be used in research related to allergic rhinitis and asthma.

For research use only. We do not sell to patients.

AZD3778 Chemical Structure

CAS No. : 485391-80-8

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•Related Small Molecules:

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View All Histamine Receptor Isoform Specific Products:

View All Isoforms

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

View All CCR Isoform Specific Products:

View All Isoforms

CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

CCR3

8.1 nM (IC₅₀)

Human H₁ Receptor

40 nM (IC₅₀)

In Vitro

AZD3778 is a CCR3 and histamine H1 receptor inhibitor, with IC₅₀ values of 8.1 nM and 40 nM against human targets, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

526.48

Formula

C₂₄H₂₉Cl₂N₃O₄S

CAS No.

485391-80-8

SMILES

O=C(N1CCC(CC1)N2CCC(CC2)OC3=CC=C(C(Cl)=C3)Cl)NS(=O)(C4=CC=C(C)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pease, J.E., et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. In: Tschammer, N. (eds) Chemokines. Topics in Medicinal Chemistry, vol 14. Springer, Cham.

[2]. Bahl A, et al. The discovery of CCR3/H1 dual antagonists with reduced hERG risk. Bioorg Med Chem Lett. 2012;22(21):6688-6693.

AZD3778 Related Classifications

Inflammation/Immunology

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD3778485391-80-8AZD 3778AZD-3778Histamine ReceptorCCRCC chemokine receptorallergic rhinitishistamineasthmaeosinophilic effectshistamine H1 receptorCCR3eotaxinInhibitorinhibitorinhibit

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