67910-12-7
Chemical Structure
11-Dehydro-thromboxane B2
- CAS No.: 67910-12-7
- Formula:C20H32O6
- Molecular Weight:368.46
IUPAC Name: (Z)-7-((2R,3S,4S)-4-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-6-oxotetrahydro-2H-pyran-3-yl)hept-5-enoic acid
InChIKey: KJYIVXDPWBUJBQ-UHHGALCXSA-N
SMILES: O=C(O)CCC/C=C\C[C@@H]([C@@H](O)C1)[C@@H](/C=C/[C@@H](O)CCCCC)OC1=O
Biological Activity: 11-Dehydro-thromboxane B2 is a stable terminal metabolite of thromboxane A2 and an agonist of the CRTH2 receptor. 11-Dehydro-TXB2 activates human eosinophils, basophils, and CRTH2-transfected BaF/3 cells through a pertussis toxin-insensitive G protein-PLC pathway, inducing intracellular calcium mobilization, morphological changes, and chemotaxis, but does not affect platelet aggregation. 11-Dehydro-thromboxane B2 is involved in thrombosis and promotes eosinophil recruitment to the lungs in allergic inflammation, and its urinary levels are used to assess the inhibitory effect of Aspirin (HY-14654) on thromboxane production. 11-Dehydro-TXB2 serves as a biomarker for research related to asthma, atopic rhinitis, nephropathy, and coronary artery disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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11-Dehydro-thromboxane B2 | 99.9% | 11-Dehydro-thromboxane B2 is a stable terminal metabolite of thromboxane A2 and an agonist of the CRTH2 receptor. 11-Dehydro-TXB2 activates human eosinophils, basophils, and CRTH2-transfected BaF/3 cells through a pertussis toxin-insensitive G protein-PLC pathway, inducing intracellular calcium mobilization, morphological changes, and chemotaxis, but does not affect platelet aggregation. 11-Dehydro-thromboxane B2 is involved in thrombosis and promotes eosinophil recruitment to the lungs in allergic inflammation, and its urinary levels are used to assess the inhibitory effect of Aspirin (HY-14654) on thromboxane production. 11-Dehydro-TXB2 serves as a biomarker for research related to asthma, atopic rhinitis, nephropathy, and coronary artery disease. | ||||||||||||||||||||
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11-Dehydro-thromboxane B2-d4 | 99.9% | 11-Dehydro-thromboxane B2-d4 is the d4-labeled 11-Dehydro-thromboxane B2 (HY-113420). 11-Dehydro-thromboxane B2 is a stable terminal metabolite of thromboxane A2 and an agonist of the CRTH2 receptor. 11-Dehydro-TXB2 activates human eosinophils, basophils, and CRTH2-transfected BaF/3 cells through a pertussis toxin-insensitive G protein-PLC pathway, inducing intracellular calcium mobilization, morphological changes, and chemotaxis, but does not affect platelet aggregation. 11-Dehydro-thromboxane B2 is involved in thrombosis and promotes eosinophil recruitment to the lungs in allergic inflammation, and its urinary levels are used to assess the inhibitory effect of Aspirin (HY-14654) on thromboxane production. 11-Dehydro-TXB2 serves as a biomarker for research related to asthma, atopic rhinitis, nephropathy, and coronary artery disease. | ||||||||||||||||||||
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11-Dehydro-thromboxane B2-13C5 | 11-Dehydro-thromboxane B2-13C5 is the 13C-labeled 11-Dehydro-thromboxane B2 (HY-113420). 11-Dehydro-thromboxane B2 is a stable terminal metabolite of thromboxane A2 and an agonist of the CRTH2 receptor. 11-Dehydro-TXB2 activates human eosinophils, basophils, and CRTH2-transfected BaF/3 cells through a pertussis toxin-insensitive G protein-PLC pathway, inducing intracellular calcium mobilization, morphological changes, and chemotaxis, but does not affect platelet aggregation. 11-Dehydro-thromboxane B2 is involved in thrombosis and promotes eosinophil recruitment to the lungs in allergic inflammation, and its urinary levels are used to assess the inhibitory effect of Aspirin (HY-14654) on thromboxane production. 11-Dehydro-TXB2 serves as a biomarker for research related to asthma, atopic rhinitis, nephropathy, and coronary artery disease. | |||||||||||||||||||||
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References
- [1]. Böhm E, et al. 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. J Biol Chem. 2004 Feb 27;279(9):7663-70.
- [2]. Hui X, et al. Establishment of 11-dehydro-thromboxane B2 time-resolved immunoassay and application in membranous nephropathy. Analytical biochemistry. 2023 Sep 15;677:115252.
- [3]. Lopez LR, et al. Platelet thromboxane (11-dehydro-Thromboxane B2) and aspirin response in patients with diabetes and coronary artery disease. World J Diabetes. 2014 Apr 15;5(2):115-27. [Content Brief]
