2. Disease Areas
  3. Inflammation or Immune System Disease
  4. Skin Inflammation
  5. Contact Dermatitis

Contact Dermatitis

Contact dermatitis is a common inflammatory skin condition resulting from direct exposure to environmental irritants or allergens, manifesting as rash, itching, redness, swelling, and skin lesions. It comprises two primary forms: irritant contact dermatitis (ICD), caused by direct damage from exogenous agents such as acids, alkalis, detergents, and certain chemicals in hair dyes or nail polish removers, and allergic contact dermatitis (ACD), driven by immune responses involving cytokines and allergen-specific CD4+ and CD8+ T cells. Heavy metals like chromium (Cr), copper (Cu), lead (Pb), nickel (Ni), gold (Au), cobalt (Co), palladium (Pd), and mercury (Hg) are significant contributors to both ACD and systemic contact dermatitis (SCD), particularly due to their widespread industrial use and potential for sensitization. These metals can induce localized or systemic reactions upon occupational or environmental exposure. Diagnosis relies on clinical evaluation and laboratory methods including patch testing, lymphocyte stimulation tests (LST), and cytokine profiling. This summary highlights the epidemiological and clinical features of ACD and SCD associated with Cr, Cu, and Pb, while also addressing the role of other heavy metals in contact hypersensitivity, excluding nickel due to recent comprehensive reviews.

Contact Dermatitis (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-108170
    Pyrethrin II 121-29-9
    Pyrethrin II is an orally active insecticidal ester of chrysanthemum acid found in Chrysanthemum cinerariifolium and C. coccineum Willd., an active constituent of pyrethrum extract with low mammalian toxicity. Pyrethrin II exhibits antiparasitic activity. Pyrethrin II can be used for the research of allergic contact dermatitis and parasitic infections.
    Pyrethrin II
  • HY-W020246
    Tetramethylthiuram monosulfide 97-74-5 99.71%
    Tetramethylthiuram monosulfide (TMTM) is an orally active microsomal monooxygenases inhibitor. Tetramethylthiuram monosulfide is used as an accelerator and activator in the processing of natural rubber and butyl rubber. Tetramethylthiuram monosulfide reduces palmitic acid incorporation into microsomal phospholipids, disrupts microsomal membrane integrity, and impairs electron transport during oxygenation. Tetramethylthiuram monosulfide can be used for the research of fungal infection, bacterial infection and allergic contact dermatitis.
    Tetramethylthiuram monosulfide
  • HY-B1644
    Fenticlor 97-24-5
    Fenticlor is a topical antibacterial agent that can be used for treating acne. Fenticlor can cause photosensitivity reactions and is a known cause of phototoxic dermatitis.
    Fenticlor