1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Prostaglandin D2

Prostaglandin D2 (Synonyms: PGD2)

Cat. No.: HY-101988
Handling Instructions

Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances. PGD2 plays a protective role by suppressing inflammation.

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Prostaglandin D2 Chemical Structure

Prostaglandin D2 Chemical Structure

CAS No. : 41598-07-6

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Description

Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice[2].

Animal Model: Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)[1]
Dosage: 5, 10, 20, or 50 pmol/min
Administration: Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00
Result: Induced sleep-wake profiles.
Molecular Weight

352.47

Formula

C₂₀H₃₂O₅

CAS No.

41598-07-6

SMILES

CCCCC[[email protected]](O)/C=C/[[email protected]@H]1[[email protected]]([[email protected]@H](O)CC1=O)C/C=C\CCCC(O)=O

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Keywords:

Prostaglandin D2PGD2Prostaglandin D 2Prostaglandin D-2PGD 2PGD-2Endogenous MetabolitePGbrainendogenoussleepprotectiveinflammationInhibitorinhibitorinhibit

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Prostaglandin D2
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