2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Prostaglandin Receptor Endogenous Metabolite
  4. Prostaglandin D2

Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances. PGD2 plays a protective role by suppressing inflammation.

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CAS No. : 41598-07-6

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Based on 4 publication(s) in Google Scholar

Other Forms of Prostaglandin D2:

Prostaglandin D2 Related Antibodies

Top Publications Citing Use of Products

    Prostaglandin D2 purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 20;13(20):1737.  [Abstract]

    RT-qPCR for CD36 levels in MGs/MΦs treated with various concentrations of Prostaglandin D2 (PGD2) (0.1-2.5 μM; 3 days). * p < 0.05 among groups, n = 3 for each group. Abbreviations: MGs/MΦs, microglia/macrophages.

    Prostaglandin D2 purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 20;13(20):1737.  [Abstract]

    WB analysis for CD36 levels in MGs/MΦs treated with various concentrations of Prostaglandin D2 (PGD2) (0.1-2.5 μM; 3 days). Abbreviations: MGs/MΦs, microglia/macrophages.

    Prostaglandin D2 purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 20;13(20):1737.  [Abstract]

    Immunohistochemistry showing microbead uptake in CD11b+ MGs/MΦs treated without Prostaglandin D2 (PGD2) (2.5 μM; 3 days) (control) (A) or with PGD2 (B) (CD11b [(A,B): red]; DAPI [(A,B): blue]). Immunohistochemistry showed the uptake of FITC+ microbeads in both control CD11b+ MGs/MΦs and PGD2-treated CD11b+ MGs/MΦs, and FITC+ microbead uptake was obviously increased in PGD2-treated CD11b+ MGs/MΦs compared to the control.

    Prostaglandin D2 purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 20;13(20):1737.  [Abstract]

    FACS analysis. The microbead uptake was significantly higher in Prostaglandin D2 (PGD2) (2.5 μM; 3 days)-treated MGs/MΦs relative to the control MGs/MΦs.

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    Human Endogenous Metabolite Microbial Metabolite

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    • Purity & Documentation

    • References

    • Customer Review

    Description

    Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

    IC50 & Target

    DP

     

    Human Endogenous Metabolite

     

    In Vivo

    Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)[1]
    Dosage: 5, 10, 20, or 50 pmol/min
    Administration: Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00
    Result: Induced sleep-wake profiles.
    Clinical Trial
    Molecular Weight

    352.47

    Formula

    C20H32O5
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)CC1=O)C/C=C\CCCC(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    Ethanol : 75 mg/mL (212.78 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8371 mL 14.1856 mL 28.3712 mL
    5 mM 0.5674 mL 2.8371 mL 5.6742 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.09 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (7.09 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.5%

    SDS (418 KB)

    COA (253 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol 1 mM 2.8371 mL 14.1856 mL 28.3712 mL 70.9280 mL
    5 mM 0.5674 mL 2.8371 mL 5.6742 mL 14.1856 mL
    10 mM 0.2837 mL 1.4186 mL 2.8371 mL 7.0928 mL
    15 mM 0.1891 mL 0.9457 mL 1.8914 mL 4.7285 mL
    20 mM 0.1419 mL 0.7093 mL 1.4186 mL 3.5464 mL
    25 mM 0.1135 mL 0.5674 mL 1.1348 mL 2.8371 mL
    30 mM 0.0946 mL 0.4729 mL 0.9457 mL 2.3643 mL
    40 mM 0.0709 mL 0.3546 mL 0.7093 mL 1.7732 mL
    50 mM 0.0567 mL 0.2837 mL 0.5674 mL 1.4186 mL
    60 mM 0.0473 mL 0.2364 mL 0.4729 mL 1.1821 mL
    80 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8866 mL
    100 mM 0.0284 mL 0.1419 mL 0.2837 mL 0.7093 mL
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    Prostaglandin D2 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Prostaglandin D241598-07-6PGD2Prostaglandin D 2Prostaglandin D-2PGD 2PGD-2Prostaglandin ReceptorEndogenous MetabolitePGbrainendogenoussleepprotectiveinflammationInhibitorinhibitorinhibit

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