Prostaglandin D2-d4
Based on 1 Customer Validation
Prostaglandin D2-d4 is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances. PGD2 plays a protective role by suppressing inflammation.
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- Reinheit: 98.81%
- CAS. Nr.: 211105-29-2
- Formel: C20H28D4O5
- Molecular Weight:356.49
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Speicherung:
Solution, -20°C, 2 years
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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Biologische Aktivität
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Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 211105-29-2
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Unlabeled Cas 41598-07-6
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Appearance Liquid
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Molecular Weight 356.49
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Formel C20H28D4O5
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Color Colorless to light yellow
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SMILES
CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)CC1=O)C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O
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Synonyms
PGD2-d4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (548 KB)
- English - EN (548 KB)
- Français - FR (548 KB)
- Deutsch - DE (548 KB)
- Norwegian - NO (548 KB)
- Español - ES (548 KB)
- Swedish - SV (548 KB)
- Italian - IT (548 KB)
- Korean - KR (548 KB)
- Portuguese - PT (548 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385(2):321-8. [Content Brief]
[3]. Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38(4):469-476. [Content Brief]
[4]. Kida T, et al. Prostaglandin D2 Attenuates NSC 125066-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11(12):e0167729. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Prostaglandin D2-d4 Related Classifications
HY-101988S Related Classifications
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