224585-45-9
Chemical Structure
SCH 79687
- CAS No.: 224585-45-9
- Formula:C18H16Cl2N4O
- Molecular Weight:375.25
InChIKey: CXNCQFJNXQAFND-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=C(CC2=CN=CN2)C=C1)NC3=CC(Cl)=CC(Cl)=C3
Biological Activity: SCH 79687 is an orally active histamine H3 receptor antagonist, with a Ki of 1.9 nM in rats and 13 nM in guinea pigs. SCH 79687 acts as a competitive antagonist against (R)-α-methylhistamine. SCH 79687 attenuates the inhibitory effect of (R)-α-methylhistamine-induced sympathetic hypertensive responses in guinea pigs. When used in combination with H1 antagonists, SCH 79687 inhibits Compound 48/80 (HY-115768)-induced nasal congestion in cats. SCH 79687 can be used for the research of allergic rhinitis[1].
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SCH 79687 | SCH 79687 is an orally active histamine H3 receptor antagonist, with a Ki of 1.9 nM in rats and 13 nM in guinea pigs. SCH 79687 acts as a competitive antagonist against (R)-α-methylhistamine. SCH 79687 attenuates the inhibitory effect of (R)-α-methylhistamine-induced sympathetic hypertensive responses in guinea pigs. When used in combination with H1 antagonists, SCH 79687 inhibits Compound 48/80 (HY-115768)-induced nasal congestion in cats. SCH 79687 can be used for the research of allergic rhinitis. | |||||||||||||||||||||
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Keywords
