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Cat. No.: HY-N21765

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Bakkenolide Iva

Bakkenolide Iva is a bakkenolide-type sesquiterpene. Bakkenolide Iva is isolated from the rhizomes of Petasites tricholobus. Bakkenolide Iva inhibits lipid peroxidation in rat brain homogenates and scavenges DPPH free radicals. Bakkenolide Iva protects cortical neurons against oxygen-glucose deprivation-induced injury and oxidative stress-induced neuronal injury. Bakkenolide Iva can be used in research on paralysis and allergic rhinitis.

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CAS No.: 915289-61-1
화학식: C₂₄H₃₂O₆S
분자량:448.57

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bakkenolide Iva Chemical Structure

CAS No.: 915289-61-1

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

In Vitro

Bakkenolide IVa (25-100 μg/mL; 1 h) exerts dose-dependent neuroprotective effects against oxygen-glucose deprivation-induced damage in primary cultured rat cortical neurons, improving viability to 72.6% at 100 μg/mL^[1].
Bakkenolide IVa (25-100 μg/mL) significantly protects primary cultured rat cortical neurons against oxidative damage, providing near-complete protection (84.6% viability) against Fe²⁺/ascorbic acid at 100 μg/mL^[1].
Bakkenolide IVa (25-100 μg/mL; 1 h) potently inhibits Fe²⁺/ascorbic acid-induced lipid peroxidation in rat brain homogenates with a maximal inhibition of 92.5% at 100 μg/mL^[1].
Bakkenolide IVa (25-100 μg/mL; 30 min) is an effective DPPH free radical scavenger, reaching 82.7% scavenging activity at 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 915289-61-1
분자량 448.57
화학식 C₂₄H₃₂O₆S
SMILES

O(C(C=C(C)C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(C=CSC)=O)CC[C@@H]3C)[H])C(=C)COC2=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wang YL, et al. Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities. Planta medica. 2009 Feb;75(3):230-5. [Content Brief]

[2]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]

[3]. Zhang FJ, et al. Anti-allergic effects of total bakkenolides from Petasites tricholobus in ovalbumin-sensitized rats. Phytotherapy research : PTR. 2011 Jan;25(1):116-21. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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