Bakkenolide Iva
Bakkenolide Iva is a bakkenolide-type sesquiterpene. Bakkenolide Iva is isolated from the rhizomes of Petasites tricholobus. Bakkenolide Iva inhibits lipid peroxidation in rat brain homogenates and scavenges DPPH free radicals. Bakkenolide Iva protects cortical neurons against oxygen-glucose deprivation-induced injury and oxidative stress-induced neuronal injury. Bakkenolide Iva can be used in research on paralysis and allergic rhinitis.
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- CAS. Nr.: 915289-61-1
- Formel: C24H32O6S
- Molecular Weight:448.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Bakkenolide IVa (25-100 μg/mL; 1 h) exerts dose-dependent neuroprotective effects against oxygen-glucose deprivation-induced damage in primary cultured rat cortical neurons, improving viability to 72.6% at 100 μg/mL[1].
Bakkenolide IVa (25-100 μg/mL) significantly protects primary cultured rat cortical neurons against oxidative damage, providing near-complete protection (84.6% viability) against Fe2+/ascorbic acid at 100 μg/mL[1].
Bakkenolide IVa (25-100 μg/mL; 1 h) potently inhibits Fe2+/ascorbic acid-induced lipid peroxidation in rat brain homogenates with a maximal inhibition of 92.5% at 100 μg/mL[1].
Bakkenolide IVa (25-100 μg/mL; 30 min) is an effective DPPH free radical scavenger, reaching 82.7% scavenging activity at 100 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 915289-61-1
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Molecular Weight 448.57
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Formel C24H32O6S
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SMILES
O(C(C=C(C)C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(C=CSC)=O)CC[C@@H]3C)[H])C(=C)COC2=O
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Structure Classification
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Wang YL, et al. Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities. Planta medica. 2009 Feb;75(3):230-5. [Content Brief]
[2]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]
[3]. Zhang FJ, et al. Anti-allergic effects of total bakkenolides from Petasites tricholobus in ovalbumin-sensitized rats. Phytotherapy research : PTR. 2011 Jan;25(1):116-21. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Bakkenolide Iva Related Classifications
HY-N21765 Related Classifications
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