1-Heptanol
Based on 1 Customer Validation
1-Heptanol (n-Heptyl alcohol) is a linear primary fatty alcohol. 1-Heptanol selectively inhibits the activating phosphorylation of SAPK/JNK and reduces the phosphorylation level of IκB-α. 1-Heptanol increases plasma membrane fluidity, decreases membrane thermal stability, alters the coupling kinetics of STIM1-ORAI1, inhibits the production of ROS and LTC4, and induces the expression of HSP70. 1-Heptanol is used in the fragrance industry due to its pleasant odor.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.50%
- CAS 番号: 111-70-6
- 分子式: C7H16O
- 分子量:116.20
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
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Help & FAQs
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HY-W032022
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生物活性
製品説明
体外実験
1-Heptanol (2.5 mM; 10 min) enhances the lateral mobility of FcεRI in RBL-2H3 cells[1].
1-Heptanol (2.5 mM; 15 min pre-incubation, present during activation) inhibits calcium mobilization by reducing extracellular Ca2+ influx in antigen-activated RBL-2H3 cells and thapsigargin-activated HEK293 cells[1].
1-Heptanol (2.5 mM; 10 min) enhances the lateral migration capacity of ORAI1 in HEK293 cells[1].
1-Heptanol (2.5 mM; 10 min pre-incubation, present during 5 min activation) enhances basal STIM1-ORAI1 coupling in resting HEK293 cells[1].
1-Heptanol (2.5 mM; 15 min) inhibits the phosphorylation of SAPK/JNK, in antigen-activated mouse bone marrow-derived mast cells (BMMCs)[1].
1-Heptanol (98%; 60 s) induces reproducible localized central corneal epithelial detachment in ex vivo human corneoscleral tissues[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BMMCs, RBL-2H3 cells, ROSA cells
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Concentration:2.5 mM; 5 mM
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Incubation Time:15 min
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Result:Did not alter annexin V-APC-dependent phosphatidylserine staining, Hoechst 33258 intracellular presence, or double staining relative to untreated cells at 2.5 mM.
Increased the percentage of annexin V-positive BMMCs and RBL-2H3 cells, with a smaller increase in double-positive cells for BMMCs at 5 mM.
Showed no significant change in staining patterns for ROSA cells at 5 mM.
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Cell Line:BMMCs
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Concentration:2.5 mM+TNP‑BSA；0.5 μg/mL
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Incubation Time:15 min
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Result:Inhibited the phosphorylation of SAPK/JNK, but not that of ERK and p38.
化学情報
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CAS 番号 111-70-6
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性状 Liquid (Density: 0.822 g/cm3)
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分子量 116.20
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分子式 C7H16O
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Color Colorless to light yellow
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SMILES
CCCCCCCO
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別名
1-Heptanol; Heptyl Alcohol; n-Heptyl alcohol
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
体外:
DMSO : ≥ 200 mg/mL (1721.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Bugajev V, et al. Enhanced Membrane Fluidization and Cholesterol Displacement by 1-Heptanol Inhibit Mast Cell Effector Functions. Cells. 2023 Aug 15;12(16):2069. [Content Brief]
[2]. Bonelli F, et al. Development and optimization of an ex vivo model of corneal epithelium damage with 1-heptanol: Investigating the influence of donor clinical parameters and MSC-sEV treatment on healing capacity. The ocular surface. 2025 Apr;36:224-236. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.6059 mL | 43.0293 mL | 86.0585 mL | 215.1463 mL |
| 5 mM | 1.7212 mL | 8.6059 mL | 17.2117 mL | 43.0293 mL | |
| 10 mM | 0.8606 mL | 4.3029 mL | 8.6059 mL | 21.5146 mL | |
| 15 mM | 0.5737 mL | 2.8686 mL | 5.7372 mL | 14.3431 mL | |
| 20 mM | 0.4303 mL | 2.1515 mL | 4.3029 mL | 10.7573 mL | |
| 25 mM | 0.3442 mL | 1.7212 mL | 3.4423 mL | 8.6059 mL | |
| 30 mM | 0.2869 mL | 1.4343 mL | 2.8686 mL | 7.1715 mL | |
| 40 mM | 0.2151 mL | 1.0757 mL | 2.1515 mL | 5.3787 mL | |
| 50 mM | 0.1721 mL | 0.8606 mL | 1.7212 mL | 4.3029 mL | |
| 60 mM | 0.1434 mL | 0.7172 mL | 1.4343 mL | 3.5858 mL | |
| 80 mM | 0.1076 mL | 0.5379 mL | 1.0757 mL | 2.6893 mL | |
| 100 mM | 0.0861 mL | 0.4303 mL | 0.8606 mL | 2.1515 mL |
1-Heptanol 関連分類
HY-W099504 関連分類
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