RBAK - RB associated KRAB zinc finger Gene

Homo sapiens

Also known as ZNF769

Gene ID: 57786 | Gene type: protein coding

About RBAK

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,045,860-5,069,487 (from NCBI)

This gene has 3 transcripts (splice variants), 88 orthologues and 174 paralogues. Ubiquitous expression in thyroid (RPKM 4.0), lymph node (RPKM 4.0) and 25 other tissues.

Summary

This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]

RBAK Products(2)

mRNA	Protein	Name
NM_001204456.2	NP_001191385.1	RB-associated KRAB zinc finger protein
NM_021163.4	NP_066986.1	RB-associated KRAB zinc finger protein

RBAK Protein Structure

KRAB

zf-H2C2_2

zf-C2H2_6

zf-H2C2_2

0
200
400
600
714 a.a.

Protein Preferred Names

Protein Names

RB-associated KRAB zinc finger protein

RB-associated KRAB repressor

Related Diseases

Diseases

Alias

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11715	RBAK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RBAK	RGD	RGD:1562875
Canis familiaris	RBAK	VGNC	VGNC:59397
Bos taurus	RBAK	VGNC	VGNC:50045
Mus musculus	RBAK	MGD	MGI:1927369