CBX3 - chromobox 3 Gene

Also Known as HECH; HP1-GAMMA; HP1Hs-gamma

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11335

About CBX3

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,201,443-26,213,607 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues and 8 paralogues. Ubiquitous expression in lymph node (RPKM 47.3), testis (RPKM 43.1) and 25 other tissues.

Summary

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

CBX3 Products (3)

mRNA	Protein	Name
NM_001410866.1	NP_001397795.1	chromobox protein homolog 3 isoform b
NM_007276.5	NP_009207.2	chromobox protein homolog 3 isoform a
NM_016587.4	NP_057671.2	chromobox protein homolog 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	19486527	GOA
enables histone methyltransferase binding	IPI IPI: Inferred from physical interaction	19486527	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19486527	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8663349	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	8663349	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	29795351	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	27248496	GOA
involved in heterochromatin formation	IDA IDA: Inferred from direct assay	17540172	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9636147	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9636147	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	29795351	GOA
located in chromatin	IDA IDA: Inferred from direct assay	11101528	GOA
part of chromatin lock complex	IPI IPI: Inferred from physical interaction	17540172	GOA
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	10504293	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	11124534	GOA
located in heterochromatin	IDA IDA: Inferred from direct assay	11124534	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17540172	GOA
located in site of DNA damage	IMP IMP: Inferred from mutant phenotype	27248496	GOA
located in spindle	IDA IDA: Inferred from direct assay	11101528	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBX3 Protein Structure

Chromo

Chromo_shadow

0
100
183 a.a.

Protein Preferred Names	Protein Names
chromobox protein homolog 3	HP1 gamma homolog

CBX3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CBX3	Q13185	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	CBX3	Q13185	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	CBX3	Q13185	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32296183
Intra	CBX3	Q13185	LBR	Homo sapiens	Q14739	Y2H	8663349
Intra	CBX3	Q13185	ZNF280D	Homo sapiens	Q6N043-2	Y2H Prey Pooling	32296183
Intra	CBX3	Q13185	ZNF280D	Homo sapiens	Q6N043-2	Validated Y2H	32296183
Intra	CBX3	Q13185	ZNF280D	Homo sapiens	Q6N043-2	Y2H Array	32296183
Intra	CBX3	Q13185	ADNP	Homo sapiens	Q9H2P0	Anti Bait CoIP	36950384
Intra	CBX3	Q13185	ADNP	Homo sapiens	Q9H2P0	Anti Tag CoIP	33961781
Intra	CBX3	Q13185	ADNP	Homo sapiens	Q9H2P0	TAP	24981860
Intra	CBX3	Q13185	ADNP	Homo sapiens	Q9H2P0	TAP	27705803
Intra	CBX3	Q13185	ADNP	Homo sapiens	Q9H2P0	TAP	21888893
Intra	CBX3	Q13185	GDF15	Homo sapiens	Q99988	Validated Y2H	32296183
Intra	CBX3	Q13185	GDF15	Homo sapiens	Q99988	Y2H Array	32296183
Intra	CBX3	Q13185	GDF15	Homo sapiens	Q99988	Y2H Prey Pooling	32296183
Intra	CBX3	Q13185	LAP3	Homo sapiens	P28838	Y2H Array	32296183
Intra	CBX3	Q13185	LAP3	Homo sapiens	P28838	Y2H Prey Pooling	32296183
Intra	CBX3	Q13185	MGA	Homo sapiens	Q8IWI9	TAP	24981860
Intra	CBX3	Q13185	MGA	Homo sapiens	Q8IWI9	TAP	27705803
Intra	CBX3	Q13185	MGA	Homo sapiens	Q8IWI9	Anti Tag CoIP	33961781
Intra	CBX3	Q13185	ADNP2	Homo sapiens	Q6IQ32	TAP	27705803
Intra	CBX3	Q13185	ADNP2	Homo sapiens	Q6IQ32	Anti Tag CoIP	33961781
Intra	CBX3	Q13185	ADNP2	Homo sapiens	Q6IQ32	Y2H Prey Pooling	32296183
Intra	CBX3	Q13185	ADNP2	Homo sapiens	Q6IQ32	Validated Y2H	32296183
Intra	CBX3	Q13185	ADNP2	Homo sapiens	Q6IQ32	Y2H Array	32296183
Intra	CBX3	Q13185	SUV39H1	Homo sapiens	O43463	TAP	27705803
Intra	CBX3	Q13185	MRPL12	Homo sapiens	P52815	Y2H Prey Pooling	32296183
Intra	CBX3	Q13185	MRPL12	Homo sapiens	P52815	Y2H Array	32296183
Intra	CBX3	Q13185	LRIF1	Homo sapiens	Q5T3J3	TAP	27705803
Intra	CBX3	Q13185	LRIF1	Homo sapiens	Q5T3J3	TAP	21888893
Intra	CBX3	Q13185	LRIF1	Homo sapiens	Q5T3J3	Anti Tag CoIP	33961781
Intra	CBX3	Q13185	LRIF1	Homo sapiens	Q5T3J3	TAP	24981860
Intra	CBX3	Q13185	LRIF1	Homo sapiens	Q5T3J3	Validated Y2H	32296183
Intra	CBX3	Q13185	PRR14	Homo sapiens	Q9BWN1	TAP	27705803
Intra	CBX3	Q13185	PRR14	Homo sapiens	Q9BWN1	Y2H Prey Pooling	32296183
Intra	CBX3	Q13185	PRR14	Homo sapiens	Q9BWN1	Validated Y2H	32296183
Intra	CBX3	Q13185	PRR14	Homo sapiens	Q9BWN1	Y2H Array	32296183
Intra	CBX3	Q13185	TRIM28	Homo sapiens	Q13263	Y2H Pooling	20936779
Intra	CBX3	Q13185	TRIM28	Homo sapiens	Q13263	TAP	27705803
Intra	CBX3	Q13185	TRIM28	Homo sapiens	Q13263	TAP	21888893
Intra	CBX3	Q13185	KMT5C	Homo sapiens	Q86Y97	Pull Down	19486527
Intra	CBX3	Q13185	H3C1	Homo sapiens	P68431	Protein Array	20871592
Intra	CBX3	Q13185	H3C1	Homo sapiens	P68431	TAP	24981860
Intra	CBX3	Q13185	H3C1	Homo sapiens	P68431	Pull Down	16415788
Intra	CBX3	Q13185	ZNF280C	Homo sapiens	Q8ND82	Validated Y2H	32296183
Intra	CBX3	Q13185	ZNF280C	Homo sapiens	Q8ND82	TAP	27705803
Cross	CBX3	Q13185	legAS4	Legionella pneumophila subsp. pneumophila	Q5ZUS4	Y2H	23797873
Cross	CBX3	Q13185	legAS4	Legionella pneumophila subsp. pneumophila	Q5ZUS4	Anti Bait CoIP	23797873
Intra	CBX3	Q13185	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Prey Pooling	32296183
Intra	CBX3	Q13185	RAD54L2	Homo sapiens	Q9Y4B4	Validated Y2H	32296183
Intra	CBX3	Q13185	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CBX3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80707	HP1 gamma Antibody (YA733)	WB, IHC-F, IHC-P, ICC/IF, IP	Mouse, Human, Monkey, Hamster, Rat
HY-P80707A	HP1 gamma Antibody (YA733)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Mouse, Human, Monkey, Hamster, Rat
HY-P85493	HP1 gamma Antibody (YA5185)	WB, ICC/IF, IP, IHC-P	Mouse, Human, Monkey, Hamster, Rat
HY-P85772	HP1 gamma Antibody (YA5464)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Hyperoxaluria, Primary, Type I	Primary Hyperoxaluria Type 1 HP1 Glycolic Aciduria Alanine-Glyoxylate Aminotransferase Deficiency Hepatic Agt Deficiency Oxalosis I Primary Hyperoxaluria, Type I Serine:Pyruvate Aminotransferase Deficiency Hyperoxaluria, Primary, Type 1 Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency Serine Pyruvate Aminotransferase Deficiency Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Oxalosis 1 Hyperoxaluria Primary 1 Hyperoxaluria Primary Type I Ph1 Primary Hyperoxaluria Type I Oxalosis Type 1 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Facioscapulohumeral Muscular Dystrophy 1	Facioscapulohumeral Muscular Dystrophy Fshd Landouzy-Dejerine Muscular Dystrophy Muscular Dystrophy, Facioscapulohumeral FSHD1 Fshd1a Muscular Dystrophy, Facioscapulohumeral, Type 1a Facioscapulohumeral Muscular Dystrophy Type 1a Fsh Muscular Dystrophy Facioscapulohumeral Muscular Dystrophy 1a Facioscapulohumeral Atrophy Facioscapulohumeral Myopathy Muscular Dystrophy, Facioscapulohumeral, Type 1 Facioscapulohumeral Muscular Dystrophy Type 1 Landouzy Dejerine Muscular Dystrophy Muscular Dystrophy, Landouzy-Dejerine Fshmd1a Facio-Scapulo-Humeral Dystrophy Facioscapulohumeral Type Progressive Muscular Dystrophy Facioscapuloperoneal Muscular Dystrophy Facioscapulohumeral Dystrophy Fsh Dystrophy Landouzy-Dejerine Dystrophy Landouzy-Dejerine Myopathy Fmd Facioscapulohumeral Muscular Dystrophy-1a Muscular Dystrophy Facioscapulohumeral Dystrophy, Muscular, Facioscapulohumeral Dystrophy, Muscular, Facioscapulohumeral, Type 1 Landouzy-Dejerine Disease Landouzy-Déjerine Atrophy Facioscapulohumeral Muscle Dystrophy Fmd - [Facioscapulohumeral Muscular Dystrophy] Fsh - [Facioscapulohumeral Muscular Dystrophy] Fshd - [Facioscapulohumeral Muscular Dystrophy] Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy Landouzy-Déjérine Muscular Dystrophy
Facioscapulohumeral Muscular Dystrophy 2, Digenic	Facioscapulohumeral Muscular Dystrophy 2 FSHD2 Fshd1b Facioscapulohumeral Muscular Dystrophy 1b Fshd2, Digenic Muscular Dystrophy, Facioscapulohumeral, Type 2 Muscular Dystrophy, Facioscapulohumeral, Type 1b Fascioscapulohumeral Muscular Dystrophy 2, Digenic Facioscapulohumeral Muscular Dystrophy Type 2 Digenic Facioscapulohumeral Muscular Dystrophy Digenic Fshd2 Facioscapulohumeral Muscular Dystrophy Type 1b Dystrophy, Muscular, Facioscapulohumeral, Type 2
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome	Icf Syndrome Immunodeficiency Syndrome, Variable Ciid Centromeric Instability, Immunodeficiency Syndrome Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16 Icf

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181089	CBX2-IN-1	Inhibitor	/	Unkown
HY-RS02010	CBX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20257	Cbx3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26765	Cbx3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CBX3	VGNC	VGNC:50017
Rattus norvegicus	CBX3	RGD	RGD:1549705
Mus musculus	CBX3	MGD	MGI:108515
Others	CBX3	NCBI