CBX2-IN-1
CBX2-IN-1 is a CBX2 inhibitor with an IC50 of 9.6 μM. CBX2-IN-1 binds the CBX2 chromodomain’s H3K27me3 binding channel, blocks interaction between CBX2 and H3K27me3, and exhibits selective affinity toward CBX2, CBX4, CBX6, CBX7, and CBX8 over CBX1, CBX3, and CBX5. CBX2-IN-1 can be used for the research of prostate cancers.
For research use only. We do not sell to patients.
- Formula: C29H27N3O3
- Molecular Weight:465.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
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CBX2 9.6 μM (IC50) |
CBX2-IN-1 (compound 37) (50 μM) inhibits CBX2 in the NanoBRET assay with an IC50 of 9.6 μM, showing key interactions with the CBX2 chromodomain’s aromatic cage and Asp51 residue[1].
CBX2-IN-1 likely exhibits selective affinity for CBX2 and closely related isoforms (CBX4, CBX6, CBX7, CBX8) over CBX1, CBX3, and CBX5 due to conserved binding interactions and sequence identity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 465.54
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Formula C29H27N3O3
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SMILES
COC1=CC=CC=C1NC(C2=CC=C(C=C2)NC(CC3=CC=C(C=C3)NCC4=CC=CC=C4)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CBX2-IN-1 Related Classifications
HY-181089 Related Classifications
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