CBX2-IN-1 

CBX2-IN-1 is a CBX2 inhibitor with an IC₅₀ of 9.6 μM. CBX2-IN-1 binds the CBX2 chromodomain’s H3K27me3 binding channel, blocks interaction between CBX2 and H3K27me3, and exhibits selective affinity toward CBX2, CBX4, CBX6, CBX7, and CBX8 over CBX1, CBX3, and CBX5. CBX2-IN-1 can be used for the research of prostate cancers^[1].

CBX2-IN-1 (compound 37) (50 μM) inhibits CBX2 in the NanoBRET assay with an IC₅₀ of 9.6 μM, showing key interactions with the CBX2 chromodomain’s aromatic cage and Asp51 residue^[1].
CBX2-IN-1 likely exhibits selective affinity for CBX2 and closely related isoforms (CBX4, CBX6, CBX7, CBX8) over CBX1, CBX3, and CBX5 due to conserved binding interactions and sequence identity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

465.54

C₂₉H₂₇N₃O₃

COC1=CC=CC=C1NC(C2=CC=C(C=C2)NC(CC3=CC=C(C=C3)NCC4=CC=CC=C4)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kawamoto Y, et al. Discovery of novel 4-aminobenzamide derivatives as small molecule CBX2 inhibitors. Bioorg Med Chem Lett. 2026;133:130526.  [Content Brief]