MGA - MAX dimerization protein MGA Gene

Also Known as MAD5; MXD5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23269

About MGA

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,621,224-41,769,940 (from NCBI)

This gene has 16 transcripts (splice variants), 293 orthologues and 16 paralogues. Ubiquitous expression in ovary (RPKM 5.9), testis (RPKM 5.5) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]

MGA Products (9)

mRNA Protein Name
NM_001080541.3 NP_001074010.2 MAX gene-associated protein isoform 2
NM_001164273.2 NP_001157745.1 MAX gene-associated protein isoform 1
NM_001400225.1 NP_001387154.1 MAX gene-associated protein isoform 3
NM_001400242.1 NP_001387171.1 MAX gene-associated protein isoform 4
NM_001400243.1 NP_001387172.1 MAX gene-associated protein isoform 5
NM_001400244.1 NP_001387173.1 MAX gene-associated protein isoform 5
NM_001400245.1 NP_001387174.1 MAX gene-associated protein isoform 5
NM_001400246.1 NP_001387175.1 MAX gene-associated protein isoform 5
NM_001400247.1 NP_001387176.1 MAX gene-associated protein isoform 5

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
Cellular Component GO Annotation Evidence References Source
part of MLL1 complex IDA
IDA: Inferred from direct assay
15960975 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGA Protein Structure

T-box

T-box: T-box (77 - 261)

HLH

HLH: Helix-loop-helix DNA-binding domain (2425 - 2474)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 3065 a.a.
Protein Preferred Names Protein Names

MAX gene-associated protein

  • MAX dimerization protein 5

MGA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MGA Q8IWI9 MAX Homo sapiens P61244
Y2H Pooling
20936779
Intra
MGA Q8IWI9 CBX3 Homo sapiens Q13185
Y2H Pooling
20936779
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spindle Cell Sarcoma

  • Sarcoma

  • Sarcoma Spindle Cell

  • Sarcoma, Spindle Cell

  • Sarcoma - Category
Blue Toe Syndrome
Plasma Cell Neoplasm

  • Plasma Cell Dyscrasia

  • Paraproteinemias

  • Plasma Cell Tumour

  • Plasmacytic Tumor

  • Multiple Myeloma

  • Plasmacytoma

  • Plasma Cell Tumours

  • Plasma Cells Dyscrasia
Psoriasis 5

  • PSORS5

  • Psoriasis Susceptibility 5

  • Psoriasis 5, Susceptibility To
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Psoriasis 3

  • PSORS3

  • Psoriasis Susceptibility 3

  • Psoriasis 3, Susceptibility To
Cholesterol Embolism

  • Atheroembolism

  • Trash Foot

  • Cholesterol Crystal Embolism

  • Purple Toe Syndrome

  • Warfarin Blue Toe Syndrome

  • Embolism, Cholesterol

  • Cholesterol Embolus Syndrome
Cataract 37

  • CTRCT37

  • Cca5

  • Cataract, Congenital, Cerulean Type, 5

  • Cataract 37, Autosomal Dominant

  • Congenital Cataract Cerulean Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99222 Teplizumab 99.73% Unkown

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P9966 Enoblituzumab Inhibitor 99.16% Phase 3
HY-P99941 Retifanlimab 96.84% Phase 3
HY-P990027 Izeltabart Inhibitor 98.62% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N3686 D-Arabitol Activator 99.92% Unkown
HY-111614 Melengestrol acetate Activator 99.76% Unkown
HY-N3686S D-Arabitol-13C Activator / Unkown
HY-N3686S1 D-Arabitol-13C-1 Activator / Unkown
HY-N3686S2 D-Arabitol-13C-2 Activator / Unkown
HY-RS08395 MGA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08396 MGAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179853 MGA-C13 / Unkown
HY-N13366 3-Methylcrotonyl CoA / Unkown
HY-RS18218 Mga Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24695 Mga Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MGA VGNC VGNC:31445
Canis familiaris MGA VGNC VGNC:43210
Felis catus MGA VGNC VGNC:63486
Rattus norvegicus MGA RGD RGD:1561597
Mus musculus MGA MGD MGI:1352483
Macaca mulatta MGA VGNC VGNC:84390
Others MGA NCBI