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  3. Melengestrol acetate

Melengestrol acetate 

Cat. No.: HY-111614
Handling Instructions

Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.

For research use only. We do not sell to patients.

Melengestrol acetate Chemical Structure

Melengestrol acetate Chemical Structure

CAS No. : 2919-66-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

In Vivo

Melengestrol acetate (s.c.; 10 mg/kg; 9 days) inhibits the growth of AT3 tumors by approximately 53%. And it also causes a 54% weight reduction of the ventral prostate and a reduction of the seminal vesicles in adult male CCFl rats[1].
Melengestrol acetate (oral administration; 10 mg/kg; 24 days) causes a 58.8% Dunning R3327-AT3 tumors growth and reduces the adrenal weight by 51.6% in rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.52

Formula

C₂₅H₃₂O₄

CAS No.
SMILES

CC([[email protected]@]1(OC(C)=O)C(C[[email protected]@]2([H])[[email protected]]3([H])C=C(C)C4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])CC[[email protected]]12C)=O)=C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (63.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5219 mL 12.6097 mL 25.2194 mL
5 mM 0.5044 mL 2.5219 mL 5.0439 mL
10 mM 0.2522 mL 1.2610 mL 2.5219 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (6.30 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MelengestrolProgesterone ReceptorNR3C3progesterone derivativeMGAcorticosteroid hormoneprostaticcancer?estrusfeed additivepregnancyInhibitorinhibitorinhibit

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Product Name:
Melengestrol acetate
Cat. No.:
HY-111614
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