PRR14 - proline rich 14 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 78994

About PRR14

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,650,778-30,656,413 (from NCBI)

This gene has 13 transcripts (splice variants), 180 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 13.5), bone marrow (RPKM 12.9) and 25 other tissues.

Summary

The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during Mitosis and reforms quickly after Mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016]

PRR14 Products (2)

mRNA Protein Name
NM_001320464.3 NP_001307393.1 proline-rich protein 14
NM_024031.5 NP_076936.1 proline-rich protein 14

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR14 Protein Structure

Tantalus

Tantalus: Drosophila Tantalus-like (458 - 517)

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  • 500
  • 585 a.a.
Protein Preferred Names Protein Names

proline-rich protein 14

PRR14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRR14 Q9BWN1 CBX3 Homo sapiens Q13185
Anti Tag CoIP
33961781
Intra
PRR14 Q9BWN1 CBX5 Homo sapiens P45973
Anti Tag CoIP
33961781
Intra
PRR14 Q9BWN1 CBX5 Homo sapiens P45973
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11224 PRR14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PRR14 VGNC VGNC:33391
Macaca mulatta PRR14 VGNC VGNC:76333
Felis catus PRR14 VGNC VGNC:64381
Rattus norvegicus PRR14 RGD RGD:1594592
Canis familiaris PRR14 VGNC VGNC:45038
Mus musculus PRR14 MGD MGI:2384565
Others PRR14 NCBI