ITGA4 - integrin subunit alpha 4 Gene

Also Known as IA4; CD49D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3676

About ITGA4

Cytogenetic location: 2q31.3 Genomic coordinates (GRCh38): 2:181,457,205-181,538,940 (from NCBI)

This gene has 11 transcripts (splice variants), 237 orthologues and 17 paralogues. Broad expression in spleen (RPKM 22.7), appendix (RPKM 22.2) and 17 other tissues.

Summary

The gene encodes a member of the Integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an Integrin that may play a role in cell motility and migration. This Integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

ITGA4 Products (2)

mRNA	Protein	Name
NM_000885.6	NP_000876.3	integrin alpha-4 isoform 1 preproprotein
NM_001316312.2	NP_001303241.1	integrin alpha-4 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to C-X3-C chemokine binding	IDA IDA: Inferred from direct assay	23125415	GOA
enables cell adhesion molecule binding	IMP IMP: Inferred from mutant phenotype	23986478	GOA
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12869515	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1542691	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell-cell adhesion mediated by integrin	IGI IGI: Inferred from genetic interaction	11078691	GOA
involved in cell-matrix adhesion	IDA IDA: Inferred from direct assay	22232704	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	18308860	GOA
involved in cell-matrix adhesion involved in ameboidal cell migration	IMP IMP: Inferred from mutant phenotype	23986478	GOA
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	11078691	GOA
involved in endodermal cell differentiation	IEP IEP: Inferred from expression pattern	23154389	GOA
involved in heterotypic cell-cell adhesion	IGI IGI: Inferred from genetic interaction	11078691	GOA
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18308860	GOA
involved in leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	1715889	GOA
involved in leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	18308860	GOA
involved in negative regulation of protein homodimerization activity	IDA IDA: Inferred from direct assay	12869515	GOA
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	35802072	GOA
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	27464494	GOA
involved in positive regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	27464494	GOA
involved in receptor clustering	IMP IMP: Inferred from mutant phenotype	23986478	GOA
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	23986478	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	1715889	GOA
part of integrin alpha4-beta1 complex	IPI IPI: Inferred from physical interaction	1542691	GOA
part of integrin alpha4-beta7 complex	IDA IDA: Inferred from direct assay	18308860	GOA
part of integrin alpha4-beta7 complex	IPI IPI: Inferred from physical interaction	22232704	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12869515	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA4 Protein Structure

VCBS

Integrin_alpha2

0
200
400
600
800
1032 a.a.

Protein Preferred Names	Protein Names
integrin alpha-4	269C wild type

ITGA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ITGA4	P13612	PXN	Homo sapiens	P49023	Affinity Chrom	10604475
Intra	ITGA4	P13612	PXN	Homo sapiens	P49023	Anti Bait CoIP	10604475
Intra	ITGA4	P13612	PXN	Homo sapiens	P49023	Pull Down	21173240
Intra	ITGA4	P13612	ITGB7	Homo sapiens	P26010	X-Ray Diffraction	22232704
Intra	ITGA4	P13612	ITGB7	Homo sapiens	P26010	Lex-A Dimerization	14681217
Intra	ITGA4	P13612	ITGB7	Homo sapiens	P26010	Anti Bait CoIP	1542691
Intra	ITGA4	P13612	ITGB7	Homo sapiens	P26010	EM	22232704
Intra	ITGA4	P13612	ITGB1	Homo sapiens	P05556	Anti Bait CoIP	1542691
Intra	ITGA4	P13612	ABI1	Homo sapiens	Q8IZP0-2	Pull Down	21173240

Cross: Cross-species interaction Intra: Intraspecies interaction

ITGA4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83456	Integrin alpha 4/CD49D Antibody (YA3201)	WB	Human
HY-P84085	Integrin alpha 4/CD49D Antibody (YA3782)	WB, FC, ELISA	Human
HY-P84085A	Integrin alpha 4/CD49D Antibody (YA3782)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 26	RP26 Retinitis Pigmentosa-26 Retinitis Pigmentosa, Type 26
Isolated Macular Dystrophy
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Progressive Multifocal Leukoencephalopathy	Pml Leukoencephalopathy, Progressive Multifocal Progressive Multifocal Leukoencephalitis Leukoencephalopathy Progressive Multifocal Pml - [Progressive Multifocal Leukoencephalopathy]
Chronic Venous Insufficiency
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Hydrocele	Testicular Hydrocele
Pertussis	Whooping Cough Bordetella Infections Bordetella Infection Bordetella Pertussis Infection Wc - Whooping Cough Whooping Cough Due To Unspecified Organism Bordetellosis Tussis Convulsiva Whooping Cough, Unspecified Organism Wc - [Whooping Cough] Whooping Cough Due To B. Parapertussis Infection Due To Bordetella Parapertussis
Relapsing-Remitting Multiple Sclerosis	Relapsing-Remitting Ms Relapsing Remitting Multiple Sclerosis Multiple Sclerosis, Relapsing-Remitting Rrms Multiple Sclerosis Relapsing-Remitting
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Vasculitis	Angiitis Autoimmune Vasculitis Systemic Vasculitis Vasculitis, Autoimmune
Venous Insufficiency	Peripheral Venous Insufficiency
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
Coronary Restenosis
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Leukocyte Adhesion Deficiency, Type I	Leukocyte Adhesion Deficiency Leukocyte Adhesion Deficiency 1 LAD1 Lad Lymphocyte Function-Associated Antigen 1 Immunodeficiency Leukocyte Adhesion Deficiency Type I Leukocyte Adhesion Deficiency Type 1 Linear Iga Bullous Dermatosis Linear Iga Dermatosis Leukocyte-Adhesion Deficiency Syndrome Lfa1 Immunodeficiency Congenital Leukocyte Adherence Deficiency Lad-I Linear Iga Disease Leukocyte Adhesion Deficiency Syndrome Lad 1 Lfa 1 Immunodeficiency Linear Immunoglobulin A Dermatosis Leucocyte Adhesion Deficiency Type 1 Leukocyte Adhesion Molecule Deficiency Type 1
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Polyarteritis Nodosa	Polyarteritis Periarteritis Nodosa Pan Periarteritis Kussmaul-Maier Disease Panarteritis Nodosa Kussmaul Disease Pan - [Polyarteritis Nodosa] Polyangiitis Panangiitis Arteritis Nodosa
Severe Pre-Eclampsia	Severe Preeclampsia Antepartum Severe Pre-Eclampsia Postpartum Severe Pre-Eclampsia Severe Pre-Eclampsia, With Delivery Severe Toxemia Severe Pre-Eclampsia, Antepartum Condition Or Complication Severe Pre-Eclampsia, Postpartum Condition Or Complication Severe Puerperal Pre-Eclampsia Severe Pre-Eclamptic Toxaemia Severe Pet - [Pre-Eclamptic Toxaemia]
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	Cutaneous T-Cell Lymphoma Cutaneous T Cell Lymphoma Lymphoma, T-Cell, Cutaneous Ctcl Lymphoma T-Cell Cutaneous
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Psoriasis
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Deficiency Anemia	Anemia Deficiency Anemias Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99184	Abrilumab		98.35%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06951	ITGA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17832	Itga4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24300	Itga4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ITGA4	VGNC	VGNC:67842
Canis familiaris	ITGA4	VGNC	VGNC:42126
Rattus norvegicus	ITGA4	RGD	RGD:1593249
Mus musculus	ITGA4	MGD	MGI:96603
Macaca mulatta	ITGA4	VGNC	VGNC:73778
Bos taurus	ITGA4	VGNC	VGNC:30316
Others	ITGA4	NCBI