Integrin alpha 5 beta 1
Integrin alpha 5 beta 1 is the principal fibronectin receptor, an RGD-dependent heterodimer assembled from CD49e and CD29. It binds fibrillar fibronectin and drives fibrillogenesis, organizing the extracellular matrix during embryogenesis, angiogenesis and wound healing; knockout of either subunit in mice is embryonic lethal with severe vascular and mesodermal defects. On tumor endothelium the heterodimer is markedly upregulated, which has motivated anti-angiogenic strategies such as volociximab and fibronectin-targeted drug delivery. Alpha 5 beta 1 also transduces outside-in signals through FAK and Src that govern cell survival and migration. Compared with alpha V beta 3, it shows higher selectivity for fibronectin over vitronectin, making it the reference receptor for fibronectin-based adhesion assays.
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Integrin alpha 5 beta 1 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
