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TNS3 - tensin 3 Gene

Also Known as TEM6; TENS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64759

About TNS3

Cytogenetic location: 7p12.3 Genomic coordinates (GRCh38): 7:47,275,154-47,582,586 (from NCBI)

This gene has 15 transcripts (splice variants), 280 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 15.0), lung (RPKM 14.4) and 25 other tissues.

Summary

Predicted to enable Phosphatase activity. Predicted to be involved in dephosphorylation and intracellular signal transduction. Predicted to act upstream of or within cell migration; lung alveolus development; and positive regulation of cell population proliferation. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

TNS3 Products (3)

mRNA	Protein	Name
NM_001410877.1	NP_001397806.1	tensin-3 isoform 1
NM_001410878.1	NP_001397807.1	tensin-3 isoform 2
NM_022748.12	NP_073585.8	tensin-3 isoform 3

TNS3 Protein Structure

PTEN_C2

SH2

PTB

0
300
600
900
1200
1445 a.a.

Protein Preferred Names	Protein Names
tensin-3	tensin-like SH2 domain containing 1

TNS3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNS3	Q68CZ2	MET	Homo sapiens	P08581	FPS	24728074
Intra	TNS3	Q68CZ2	KIT	Homo sapiens	P10721	FPS	24728074
Intra	TNS3	Q68CZ2	EGFR	Homo sapiens	P00533	Anti Tag CoIP	24658140
Intra	TNS3	Q68CZ2	SRC	Homo sapiens	P12931	Anti Bait CoIP	19732724
Intra	TNS3	Q68CZ2	SRC	Homo sapiens	P12931	Protein Kinase Assay	19732724
Intra	TNS3	Q68CZ2	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	TNS3	Q68CZ2	BCAR1	Homo sapiens	P56945	Anti Bait CoIP	19732724
Intra	TNS3	Q68CZ2	BCAR1	Homo sapiens	P56945	Pull Down	19732724
Intra	TNS3	Q68CZ2	PTK2	Homo sapiens	Q05397	Pull Down	19732724
Intra	TNS3	Q68CZ2	PTK2	Homo sapiens	Q05397	IF	19732724
Intra	TNS3	Q68CZ2	ERBB3	Homo sapiens	P21860	Protein Array	16273093
Intra	TNS3	Q68CZ2	CDH1	Homo sapiens	P12830	Anti Bait CoIP	19732724

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Thyroid Tumor
Primary Syphilis	Early Symptomatic Syphilis Early Syphilis, Symptomatic Symptomatic Early Syphilis
Scoliosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14869	TNS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNS3	VGNC	VGNC:79324
Bos taurus	TNS3	VGNC	VGNC:36209
Canis familiaris	TNS3	VGNC	VGNC:51833
Felis catus	TNS3	VGNC	VGNC:66437
Rattus norvegicus	TNS3	RGD	RGD:1564174
Mus musculus	TNS3	MGD	MGI:2443012
Others	TNS3	NCBI