BI-0319
BI-0319 is a selective PTK2/FAK PROTAC degrader. BI-0319 can reduce cancer cells viability inhibit proliferation and invasion. BI-0319 can be used for the research of cancer, such as liver cancer.
(Pink: FAK ligand (HY-43760); Blue: VHL ligand (HY-125845); Black: linker (HY-140189)).
For research use only. We do not sell to patients.
The BI-0319 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
- CAS No.: 2341740-85-8
- Formula: C52H59F3N8O11S
- Molecular Weight:1061.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 2341740-85-8
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Molecular Weight 1061.13
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Formula C52H59F3N8O11S
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SMILES
O=C1CCC2=CC=CC(OC3=NC(NC4=C(C=C(C=C4)C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)=O)OC)=NC=C3C(F)(F)F)=C21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. [Content Brief]
[2]. Toffoli L, et al. FAK inhibition disrupts tumor growth, apoptosis, and transcriptional regulation in GI-NETs. Endocr Oncol. 2025 Aug 14;5(1):e250052. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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