2341740-85-8
2341740-85-8
Chemical Structure
BI-0319
- CAS No.: 2341740-85-8
- Formula:C52H59F3N8O11S
- Molecular Weight:1061.13
InChIKey: UVVQLQQNGHYTOL-JIVXZRRKSA-N
SMILES: O=C1CCC2=CC=CC(OC3=NC(NC4=C(C=C(C=C4)C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)=O)OC)=NC=C3C(F)(F)F)=C21
Biological Activity: BI-0319 is a selective PTK2/FAK PROTAC degrader. BI-0319 can reduce cancer cells viability inhibit proliferation and invasion. BI-0319 can be used for the research of cancer, such as liver cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BI-0319 | BI-0319 is a selective PTK2/FAK PROTAC degrader. BI-0319 can reduce cancer cells viability inhibit proliferation and invasion. BI-0319 can be used for the research of cancer, such as liver cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. [Content Brief]
- [2]. Toffoli L, et al. FAK inhibition disrupts tumor growth, apoptosis, and transcriptional regulation in GI-NETs. Endocr Oncol. 2025 Aug 14;5(1):e250052. [Content Brief]
Keywords
