PIK3R3 - phosphoinositide-3-kinase regulatory subunit 3 Gene
Also Known as p55; p55PIK; p55-GAMMA
Species: Homo sapiens
About PIK3R3
This gene has 7 transcripts (splice variants), 277 orthologues and 2 paralogues. Broad expression in testis (RPKM 19.6), fat (RPKM 8.4) and 20 other tissues.
Summary
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated Protein Tyrosine Kinases to regulate their activity. [provided by RefSeq, Jun 2016]
PIK3R3 Products (11)
| mRNA | Protein | Name |
|---|---|---|
| NM_001114172.1 | NP_001107644.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1 |
| NM_001303428.1 | NP_001290357.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3 |
| NM_001303429.2 | NP_001290358.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4 |
| NM_001328648.1 | NP_001315577.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5 |
| NM_001328649.1 | NP_001315578.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5 |
| NM_001328650.1 | NP_001315579.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5 |
| NM_001328651.1 | NP_001315580.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5 |
| NM_001328652.2 | NP_001315581.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 6 |
| NM_001328653.2 | NP_001315582.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7 |
| NM_001328654.2 | NP_001315583.1 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 8 |
| NM_003629.4 | NP_003620.3 | phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables phosphotyrosine residue binding |
IPI
IPI: Inferred from physical interaction
|
20624904 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16273093 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cell migration involved in sprouting angiogenesis |
IGI
IGI: Inferred from genetic interaction
|
28341552 | GOA |
| involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction |
IMP
IMP: Inferred from mutant phenotype
|
28341552 | GOA |
| involved in positive regulation of gene expression |
IMP
IMP: Inferred from mutant phenotype
|
28341552 | GOA |
| involved in positive regulation of protein phosphorylation |
IMP
IMP: Inferred from mutant phenotype
|
28341552 | GOA |
PIK3R3 Protein Structure
SH2: SH2 domain (65 - 140)
SH2: SH2 domain (358 - 432)
- 0
- 100
- 200
- 300
- 400
- 461 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
phosphatidylinositol 3-kinase regulatory subunit gamma |
|
PIK3R3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PIK3R3 | Q92569 | PTK2 | Homo sapiens | I6L996 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PTK2 | Homo sapiens | I6L996 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CCDC196 | Homo sapiens | A0A1B0GWI1 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CCDC196 | Homo sapiens | A0A1B0GWI1 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SPMIP6 | Homo sapiens | Q8NCR6 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SPMIP6 | Homo sapiens | Q8NCR6 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PBX4 | Homo sapiens | Q9BYU1 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PBX4 | Homo sapiens | Q9BYU1 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PBX4 | Homo sapiens | Q9BYU1 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PLAAT4 | Homo sapiens | Q9UL19 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PLAAT4 | Homo sapiens | Q9UL19 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PLAAT4 | Homo sapiens | Q9UL19 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | MET | Homo sapiens | P08581 | 24728074 | |
|
Intra
|
PIK3R3 | Q92569 | PARD6A | Homo sapiens | Q9NPB6-2 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | STAT5B | Homo sapiens | P51692 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | STAT5B | Homo sapiens | P51692 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ARID4B | Homo sapiens | Q4LE39-3 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ARID4B | Homo sapiens | Q4LE39-3 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | L3MBTL3 | Homo sapiens | Q96JM7-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | L3MBTL3 | Homo sapiens | Q96JM7-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | L3MBTL3 | Homo sapiens | Q96JM7-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CIMIP2B | Homo sapiens | A8MTA8-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CIMIP2B | Homo sapiens | A8MTA8-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CHRDL2 | Homo sapiens | Q6WN34-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CHRDL2 | Homo sapiens | Q6WN34-2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CCDC89 | Homo sapiens | Q8N998 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CCDC89 | Homo sapiens | Q8N998 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SPATA32 | Homo sapiens | Q96LK8 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SPATA32 | Homo sapiens | Q96LK8 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SPATA32 | Homo sapiens | Q96LK8 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | FNDC8 | Homo sapiens | Q8TC99 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | FNDC8 | Homo sapiens | Q8TC99 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | KIT | Homo sapiens | P10721 | 24728074 | |
|
Intra
|
PIK3R3 | Q92569 | WDFY3 | Homo sapiens | Q8IZQ1 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | WDFY3 | Homo sapiens | Q8IZQ1 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | C3orf36 | Homo sapiens | Q3SXR2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | C3orf36 | Homo sapiens | Q3SXR2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SPSB2 | Homo sapiens | Q99619 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | SPSB2 | Homo sapiens | Q99619 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | LAP3 | Homo sapiens | P28838 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | LAP3 | Homo sapiens | P28838 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | BLZF1 | Homo sapiens | Q9H2G9 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | BLZF1 | Homo sapiens | Q9H2G9 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | BLZF1 | Homo sapiens | Q9H2G9 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PIK3CB | Homo sapiens | P42338 | 28514442 | |
|
Intra
|
PIK3R3 | Q92569 | PIK3CB | Homo sapiens | P42338 | 33961781 | |
|
Intra
|
PIK3R3 | Q92569 | PIK3CB | Homo sapiens | P42338 | 22402981 | |
|
Intra
|
PIK3R3 | Q92569 | PLEKHS1 | Homo sapiens | Q5SXH7-1 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | PRKAR1B | Homo sapiens | P31321 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PRKAR1B | Homo sapiens | P31321 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SERTAD2 | Homo sapiens | Q14140 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SERTAD2 | Homo sapiens | Q14140 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | RBP7 | Homo sapiens | Q96R05 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | RBP7 | Homo sapiens | Q96R05 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | NEBL | Homo sapiens | O76041 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | NEBL | Homo sapiens | O76041 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | EGFR | Homo sapiens | P00533 | 25241761 | |
|
Intra
|
PIK3R3 | Q92569 | EGFR | Homo sapiens | P00533 | 16273093 | |
|
Intra
|
PIK3R3 | Q92569 | ZBTB18 | Homo sapiens | Q99592 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ZBTB18 | Homo sapiens | Q99592 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ZBTB18 | Homo sapiens | Q99592 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | OLIG1 | Homo sapiens | Q8TAK6 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | OLIG1 | Homo sapiens | Q8TAK6 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | SOCS4 | Homo sapiens | Q8WXH5 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | ZNF620 | Homo sapiens | Q6ZNG0 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ZNF620 | Homo sapiens | Q6ZNG0 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PELI3 | Homo sapiens | Q8N2H9 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | PELI3 | Homo sapiens | Q8N2H9 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | PELI3 | Homo sapiens | Q8N2H9 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | HTT | Homo sapiens | P42858 | 17500595 | |
|
Intra
|
PIK3R3 | Q92569 | SH2D2A | Homo sapiens | Q9NP31 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | IRS1 | Homo sapiens | P35568 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | IRS1 | Homo sapiens | P35568 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | GAB1 | Homo sapiens | Q13480 | 24728074 | |
|
Intra
|
PIK3R3 | Q92569 | CBL | Homo sapiens | P22681 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | CBL | Homo sapiens | P22681 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | OTUD7B | Homo sapiens | Q6GQQ9 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | OTUD7B | Homo sapiens | Q6GQQ9 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | OTUD7B | Homo sapiens | Q6GQQ9 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | ARL6IP4 | Homo sapiens | Q66PJ3-4 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | ARL6IP4 | Homo sapiens | Q66PJ3-4 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | AR | Homo sapiens | P10275 | 24728074 | |
|
Intra
|
PIK3R3 | Q92569 | SRC | Homo sapiens | P12931 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | RUSC1 | Homo sapiens | Q9BVN2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | RUSC1 | Homo sapiens | Q9BVN2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | RUSC1 | Homo sapiens | Q9BVN2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ERBB2 | Homo sapiens | P04626 | 16273093 | |
|
Intra
|
PIK3R3 | Q92569 | PTK2 | Homo sapiens | Q05397 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | PTK2 | Homo sapiens | Q05397 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | ITGB3BP | Homo sapiens | Q13352 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ITGB3BP | Homo sapiens | Q13352 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | DRAP1 | Homo sapiens | Q14919 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | DRAP1 | Homo sapiens | Q14919 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ANTKMT | Homo sapiens | Q9BQD7 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ANTKMT | Homo sapiens | Q9BQD7 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ANTKMT | Homo sapiens | Q9BQD7 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PIK3CD | Homo sapiens | O00329 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PIK3CD | Homo sapiens | O00329 | 33961781 | |
|
Intra
|
PIK3R3 | Q92569 | PIK3CD | Homo sapiens | O00329 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PIK3CD | Homo sapiens | O00329 | 28514442 | |
|
Intra
|
PIK3R3 | Q92569 | ERBB3 | Homo sapiens | P21860 | 16273093 | |
|
Intra
|
PIK3R3 | Q92569 | FRS3 | Homo sapiens | O43559 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | FRS3 | Homo sapiens | O43559 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | KIAA0408 | Homo sapiens | Q6ZU52 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | KIAA0408 | Homo sapiens | Q6ZU52 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CEP19 | Homo sapiens | Q96LK0 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | CEP19 | Homo sapiens | Q96LK0 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CEP19 | Homo sapiens | Q96LK0 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CEP19 | Homo sapiens | Q96LK0 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SSBP4 | Homo sapiens | Q9BWG4 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SSBP4 | Homo sapiens | Q9BWG4 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | SSBP4 | Homo sapiens | Q9BWG4 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | TASOR2 | Homo sapiens | Q5VWN6 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | TASOR2 | Homo sapiens | Q5VWN6 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | TNNI1 | Homo sapiens | P19237 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | TNNI1 | Homo sapiens | P19237 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | CRYBA2 | Homo sapiens | P53672 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | CRYBA2 | Homo sapiens | P53672 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | METTL27 | Homo sapiens | Q8N6F8 | 25814554 | |
|
Intra
|
PIK3R3 | Q92569 | NAB2 | Homo sapiens | Q15742 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | NAB2 | Homo sapiens | Q15742 | 32296183 | |
|
Intra
|
PIK3R3 | Q92569 | HCK | Homo sapiens | P08631-2 | 25814554 |
PIK3R3 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80866 | PI3 Kinase p55 gamma Antibody | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P80866A | PI3 Kinase p55 gamma Antibody (YA4639) | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P80866AA | PI3 Kinase p55 gamma Antibody (YA4639)(PBS only) | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Asbestos-Related Lung Carcinoma |
|
|
| Cervical Non-Keratinizing Squamous Cell Carcinoma |
|
|
| Colorectal Cancer |
|
|
| Lung Cancer |
|
|
| Endometrial Cancer |
|
|
| Breast Cancer |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | PIK3R3 | RGD | RGD:621042 |
| Mus musculus | PIK3R3 | MGD | MGI:109277 |
| Others | PIK3R3 | NCBI |