PIK3R3 - phosphoinositide-3-kinase regulatory subunit 3 Gene

Also Known as p55; p55PIK; p55-GAMMA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8503

About PIK3R3

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:46,040,140-46,174,901 (from NCBI)

This gene has 7 transcripts (splice variants), 277 orthologues and 2 paralogues. Broad expression in testis (RPKM 19.6), fat (RPKM 8.4) and 20 other tissues.

Summary

Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated Protein Tyrosine Kinases to regulate their activity. [provided by RefSeq, Jun 2016]

PIK3R3 Products (11)

mRNA Protein Name
NM_001114172.1 NP_001107644.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1
NM_001303428.1 NP_001290357.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3
NM_001303429.2 NP_001290358.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4
NM_001328648.1 NP_001315577.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5
NM_001328649.1 NP_001315578.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5
NM_001328650.1 NP_001315579.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5
NM_001328651.1 NP_001315580.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5
NM_001328652.2 NP_001315581.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 6
NM_001328653.2 NP_001315582.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7
NM_001328654.2 NP_001315583.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 8
NM_003629.4 NP_003620.3 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1
Molecular Function GO Annotation Evidence References Source
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
20624904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration involved in sprouting angiogenesis IGI
IGI: Inferred from genetic interaction
28341552 GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
28341552 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28341552 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
28341552 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3R3 Protein Structure

SH2

SH2: SH2 domain (65 - 140)

SH2

SH2: SH2 domain (358 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3-kinase regulatory subunit gamma

  • PI3-kinase regulatory subunit gamma

PIK3R3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PIK3R3 Q92569 PTK2 Homo sapiens I6L996 32296183
Intra
PIK3R3 Q92569 PTK2 Homo sapiens I6L996 32296183
Intra
PIK3R3 Q92569 CCDC196 Homo sapiens A0A1B0GWI1 32296183
Intra
PIK3R3 Q92569 CCDC196 Homo sapiens A0A1B0GWI1 32296183
Intra
PIK3R3 Q92569 SPMIP6 Homo sapiens Q8NCR6 32296183
Intra
PIK3R3 Q92569 SPMIP6 Homo sapiens Q8NCR6 32296183
Intra
PIK3R3 Q92569 PBX4 Homo sapiens Q9BYU1 32296183
Intra
PIK3R3 Q92569 PBX4 Homo sapiens Q9BYU1 32296183
Intra
PIK3R3 Q92569 PBX4 Homo sapiens Q9BYU1 32296183
Intra
PIK3R3 Q92569 PLAAT4 Homo sapiens Q9UL19 32296183
Intra
PIK3R3 Q92569 PLAAT4 Homo sapiens Q9UL19 32296183
Intra
PIK3R3 Q92569 PLAAT4 Homo sapiens Q9UL19 32296183
Intra
PIK3R3 Q92569 MET Homo sapiens P08581
FPS
24728074
Intra
PIK3R3 Q92569 PARD6A Homo sapiens Q9NPB6-2 25814554
Intra
PIK3R3 Q92569 STAT5B Homo sapiens P51692 32296183
Intra
PIK3R3 Q92569 STAT5B Homo sapiens P51692 32296183
Intra
PIK3R3 Q92569 ARID4B Homo sapiens Q4LE39-3 32296183
Intra
PIK3R3 Q92569 ARID4B Homo sapiens Q4LE39-3 32296183
Intra
PIK3R3 Q92569 L3MBTL3 Homo sapiens Q96JM7-2 32296183
Intra
PIK3R3 Q92569 L3MBTL3 Homo sapiens Q96JM7-2 32296183
Intra
PIK3R3 Q92569 L3MBTL3 Homo sapiens Q96JM7-2 32296183
Intra
PIK3R3 Q92569 DISC1 Homo sapiens Q9NRI5-2 32296183
Intra
PIK3R3 Q92569 DISC1 Homo sapiens Q9NRI5-2 32296183
Intra
PIK3R3 Q92569 DISC1 Homo sapiens Q9NRI5-2 32296183
Intra
PIK3R3 Q92569 CIMIP2B Homo sapiens A8MTA8-2 32296183
Intra
PIK3R3 Q92569 CIMIP2B Homo sapiens A8MTA8-2 32296183
Intra
PIK3R3 Q92569 CHRDL2 Homo sapiens Q6WN34-2 32296183
Intra
PIK3R3 Q92569 CHRDL2 Homo sapiens Q6WN34-2 32296183
Intra
PIK3R3 Q92569 CCDC89 Homo sapiens Q8N998 32296183
Intra
PIK3R3 Q92569 CCDC89 Homo sapiens Q8N998 32296183
Intra
PIK3R3 Q92569 SPATA32 Homo sapiens Q96LK8 32296183
Intra
PIK3R3 Q92569 SPATA32 Homo sapiens Q96LK8 32296183
Intra
PIK3R3 Q92569 SPATA32 Homo sapiens Q96LK8 32296183
Intra
PIK3R3 Q92569 FNDC8 Homo sapiens Q8TC99 32296183
Intra
PIK3R3 Q92569 FNDC8 Homo sapiens Q8TC99 32296183
Intra
PIK3R3 Q92569 KIT Homo sapiens P10721
FPS
24728074
Intra
PIK3R3 Q92569 WDFY3 Homo sapiens Q8IZQ1 25814554
Intra
PIK3R3 Q92569 WDFY3 Homo sapiens Q8IZQ1 25814554
Intra
PIK3R3 Q92569 C3orf36 Homo sapiens Q3SXR2 32296183
Intra
PIK3R3 Q92569 C3orf36 Homo sapiens Q3SXR2 32296183
Intra
PIK3R3 Q92569 SPSB2 Homo sapiens Q99619 25814554
Intra
PIK3R3 Q92569 SPSB2 Homo sapiens Q99619 25814554
Intra
PIK3R3 Q92569 LAP3 Homo sapiens P28838 32296183
Intra
PIK3R3 Q92569 LAP3 Homo sapiens P28838 32296183
Intra
PIK3R3 Q92569 BLZF1 Homo sapiens Q9H2G9 32296183
Intra
PIK3R3 Q92569 BLZF1 Homo sapiens Q9H2G9 32296183
Intra
PIK3R3 Q92569 BLZF1 Homo sapiens Q9H2G9 32296183
Intra
PIK3R3 Q92569 PIK3CB Homo sapiens P42338 28514442
Intra
PIK3R3 Q92569 PIK3CB Homo sapiens P42338 33961781
Intra
PIK3R3 Q92569 PIK3CB Homo sapiens P42338 22402981
Intra
PIK3R3 Q92569 PLEKHS1 Homo sapiens Q5SXH7-1 25814554
Intra
PIK3R3 Q92569 PRKAR1B Homo sapiens P31321 32296183
Intra
PIK3R3 Q92569 PRKAR1B Homo sapiens P31321 32296183
Intra
PIK3R3 Q92569 SERTAD2 Homo sapiens Q14140 32296183
Intra
PIK3R3 Q92569 SERTAD2 Homo sapiens Q14140 32296183
Intra
PIK3R3 Q92569 RBP7 Homo sapiens Q96R05 25814554
Intra
PIK3R3 Q92569 RBP7 Homo sapiens Q96R05 25814554
Intra
PIK3R3 Q92569 NEBL Homo sapiens O76041 32296183
Intra
PIK3R3 Q92569 NEBL Homo sapiens O76041 32296183
Intra
PIK3R3 Q92569 EGFR Homo sapiens P00533
PLA
25241761
Intra
PIK3R3 Q92569 EGFR Homo sapiens P00533 16273093
Intra
PIK3R3 Q92569 ZBTB18 Homo sapiens Q99592 32296183
Intra
PIK3R3 Q92569 ZBTB18 Homo sapiens Q99592 32296183
Intra
PIK3R3 Q92569 ZBTB18 Homo sapiens Q99592 32296183
Intra
PIK3R3 Q92569 OLIG1 Homo sapiens Q8TAK6 25814554
Intra
PIK3R3 Q92569 OLIG1 Homo sapiens Q8TAK6 25814554
Intra
PIK3R3 Q92569 SOCS4 Homo sapiens Q8WXH5 25814554
Intra
PIK3R3 Q92569 ZNF620 Homo sapiens Q6ZNG0 32296183
Intra
PIK3R3 Q92569 ZNF620 Homo sapiens Q6ZNG0 32296183
Intra
PIK3R3 Q92569 PELI3 Homo sapiens Q8N2H9 25814554
Intra
PIK3R3 Q92569 PELI3 Homo sapiens Q8N2H9 25814554
Intra
PIK3R3 Q92569 PELI3 Homo sapiens Q8N2H9 25814554
Intra
PIK3R3 Q92569 HTT Homo sapiens P42858
Y2H
17500595
Intra
PIK3R3 Q92569 SH2D2A Homo sapiens Q9NP31 25814554
Intra
PIK3R3 Q92569 IRS1 Homo sapiens P35568 25814554
Intra
PIK3R3 Q92569 IRS1 Homo sapiens P35568 25814554
Intra
PIK3R3 Q92569 GAB1 Homo sapiens Q13480
FPS
24728074
Intra
PIK3R3 Q92569 CBL Homo sapiens P22681 25814554
Intra
PIK3R3 Q92569 CBL Homo sapiens P22681 25814554
Intra
PIK3R3 Q92569 OTUD7B Homo sapiens Q6GQQ9 25814554
Intra
PIK3R3 Q92569 OTUD7B Homo sapiens Q6GQQ9 25814554
Intra
PIK3R3 Q92569 OTUD7B Homo sapiens Q6GQQ9 25814554
Intra
PIK3R3 Q92569 ARL6IP4 Homo sapiens Q66PJ3-4 25814554
Intra
PIK3R3 Q92569 ARL6IP4 Homo sapiens Q66PJ3-4 25814554
Intra
PIK3R3 Q92569 AR Homo sapiens P10275
FPS
24728074
Intra
PIK3R3 Q92569 SRC Homo sapiens P12931 25814554
Intra
PIK3R3 Q92569 RUSC1 Homo sapiens Q9BVN2 32296183
Intra
PIK3R3 Q92569 RUSC1 Homo sapiens Q9BVN2 32296183
Intra
PIK3R3 Q92569 RUSC1 Homo sapiens Q9BVN2 32296183
Intra
PIK3R3 Q92569 ERBB2 Homo sapiens P04626 16273093
Intra
PIK3R3 Q92569 PTK2 Homo sapiens Q05397 25814554
Intra
PIK3R3 Q92569 PTK2 Homo sapiens Q05397 25814554
Intra
PIK3R3 Q92569 ITGB3BP Homo sapiens Q13352 32296183
Intra
PIK3R3 Q92569 ITGB3BP Homo sapiens Q13352 32296183
Intra
PIK3R3 Q92569 DRAP1 Homo sapiens Q14919 32296183
Intra
PIK3R3 Q92569 DRAP1 Homo sapiens Q14919 32296183
Intra
PIK3R3 Q92569 ANTKMT Homo sapiens Q9BQD7 32296183
Intra
PIK3R3 Q92569 ANTKMT Homo sapiens Q9BQD7 32296183
Intra
PIK3R3 Q92569 ANTKMT Homo sapiens Q9BQD7 32296183
Intra
PIK3R3 Q92569 PIK3CD Homo sapiens O00329 32296183
Intra
PIK3R3 Q92569 PIK3CD Homo sapiens O00329 33961781
Intra
PIK3R3 Q92569 PIK3CD Homo sapiens O00329 32296183
Intra
PIK3R3 Q92569 PIK3CD Homo sapiens O00329 28514442
Intra
PIK3R3 Q92569 ERBB3 Homo sapiens P21860 16273093
Intra
PIK3R3 Q92569 FRS3 Homo sapiens O43559 25814554
Intra
PIK3R3 Q92569 FRS3 Homo sapiens O43559 25814554
Intra
PIK3R3 Q92569 KIAA0408 Homo sapiens Q6ZU52 32296183
Intra
PIK3R3 Q92569 KIAA0408 Homo sapiens Q6ZU52 32296183
Intra
PIK3R3 Q92569 CEP19 Homo sapiens Q96LK0 25814554
Intra
PIK3R3 Q92569 CEP19 Homo sapiens Q96LK0 32296183
Intra
PIK3R3 Q92569 CEP19 Homo sapiens Q96LK0 32296183
Intra
PIK3R3 Q92569 CEP19 Homo sapiens Q96LK0 32296183
Intra
PIK3R3 Q92569 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
PIK3R3 Q92569 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
PIK3R3 Q92569 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
PIK3R3 Q92569 ENKD1 Homo sapiens Q9H0I2 32296183
Intra
PIK3R3 Q92569 ENKD1 Homo sapiens Q9H0I2 32296183
Intra
PIK3R3 Q92569 ENKD1 Homo sapiens Q9H0I2 32296183
Intra
PIK3R3 Q92569 SSBP4 Homo sapiens Q9BWG4 32296183
Intra
PIK3R3 Q92569 SSBP4 Homo sapiens Q9BWG4 32296183
Intra
PIK3R3 Q92569 SSBP4 Homo sapiens Q9BWG4 32296183
Intra
PIK3R3 Q92569 TASOR2 Homo sapiens Q5VWN6 32296183
Intra
PIK3R3 Q92569 TASOR2 Homo sapiens Q5VWN6 32296183
Intra
PIK3R3 Q92569 TNNI1 Homo sapiens P19237 32296183
Intra
PIK3R3 Q92569 TNNI1 Homo sapiens P19237 32296183
Intra
PIK3R3 Q92569 CRYBA2 Homo sapiens P53672 25814554
Intra
PIK3R3 Q92569 CRYBA2 Homo sapiens P53672 25814554
Intra
PIK3R3 Q92569 METTL27 Homo sapiens Q8N6F8 25814554
Intra
PIK3R3 Q92569 NAB2 Homo sapiens Q15742 32296183
Intra
PIK3R3 Q92569 NAB2 Homo sapiens Q15742 32296183
Intra
PIK3R3 Q92569 HCK Homo sapiens P08631-2 25814554
Cross: Cross-species interaction Intra: Intraspecies interaction

PIK3R3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80866 PI3 Kinase p55 gamma Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P80866A PI3 Kinase p55 gamma Antibody (YA4639) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P80866AA PI3 Kinase p55 gamma Antibody (YA4639)(PBS only) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Asbestos-Related Lung Carcinoma
Cervical Non-Keratinizing Squamous Cell Carcinoma
Colorectal Cancer
  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon

Lung Cancer
  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma

Endometrial Cancer
  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer

Breast Cancer
  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PIK3R3 RGD RGD:621042
Mus musculus PIK3R3 MGD MGI:109277
Others PIK3R3 NCBI