OTUD7B - OTU deubiquitinase 7B Gene

Homo sapiens

Also known as ZA20D1; CEZANNE

Gene ID: 56957 | Gene type: protein coding

About OTUD7B

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:149,937,812-150,067,653 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues.

Summary

Enables Lys48-specific Deubiquitinase activity and thiol-dependent Deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

OTUD7B Products(1)

mRNA	Protein	Name
NM_020205.4	NP_064590.2	OTU domain-containing protein 7B

OTUD7B Protein Structure

UBA_4

OTU

0
200
400
600
843 a.a.

Protein Preferred Names

Protein Names

OTU domain-containing protein 7B

OTU domain containing 7B

Related Diseases

Diseases

Alias

Salivary Gland Adenoid Cystic Carcinoma

Cylindroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09877	OTUD7B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OTUD7B	MGD	MGI:2654703
Macaca mulatta	OTUD7B	VGNC	VGNC:75634
Felis catus	OTUD7B	VGNC	VGNC:64003
Rattus norvegicus	OTUD7B	RGD	RGD:1308111
Bos taurus	OTUD7B	VGNC	VGNC:32500
Canis familiaris	OTUD7B	VGNC	VGNC:44191
Others	OTUD7B	NCBI

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