OTUD7B - OTU deubiquitinase 7B Gene

Also Known as ZA20D1; CEZANNE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56957

About OTUD7B

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:149,937,812-150,067,653 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues.

Summary

Enables Lys48-specific Deubiquitinase activity and thiol-dependent Deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

OTUD7B Products (1)

mRNA Protein Name
NM_020205.4 NP_064590.2 OTU domain-containing protein 7B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K48-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
21097510 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
23827681 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11463333 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
11463333 GOA
acts upstream of negative regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
21097510 GOA
involved in negative regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
21097510 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21097510 GOA
involved in protein K11-linked deubiquitination IDA
IDA: Inferred from direct assay
20622874 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
21097510 GOA
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
20622874 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11463333 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11463333 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUD7B Protein Structure

UBA_4

UBA_4: UBA-like domain (9 - 41)

OTU

OTU: OTU-like cysteine protease (189 - 359)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 843 a.a.
Protein Preferred Names Protein Names

OTU domain-containing protein 7B

  • OTU domain containing 7B

OTUD7B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OTUD7B Q6GQQ9 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra
OTUD7B Q6GQQ9 SPART Homo sapiens Q8N0X7
Validated Y2H
32296183
Intra
OTUD7B Q6GQQ9 CDIP1 Homo sapiens Q9H305
Validated Y2H
32296183
Intra
OTUD7B Q6GQQ9 HSFY1 Homo sapiens Q96LI6
Validated Y2H
32296183
Intra
OTUD7B Q6GQQ9 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
32296183
Intra
OTUD7B Q6GQQ9 CCDC50 Homo sapiens Q8IVM0
Anti Tag CoIP
18029035
Intra
OTUD7B Q6GQQ9 CCDC50 Homo sapiens Q8IVM0
Y2H
18029035
Intra
OTUD7B Q6GQQ9 CCDC50 Homo sapiens Q8IVM0
IF
18029035
Intra
OTUD7B Q6GQQ9 CCDC50 Homo sapiens Q8IVM0
Pull Down
18029035
Intra
OTUD7B Q6GQQ9 CCDC50 Homo sapiens Q8IVM0
Anti Bait CoIP
18029035
Intra
OTUD7B Q6GQQ9 OTULIN Homo sapiens Q96BN8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

OTUD7B Antibodies

Cat. No. Product Name Application Reactivity
HY-P89611 OTUD7B Antibody (YA8955) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Salivary Gland Adenoid Cystic Carcinoma

  • Cylindroma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09877 OTUD7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20186 Otud7b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26690 Otud7b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus OTUD7B MGD MGI:2654703
Macaca mulatta OTUD7B VGNC VGNC:75634
Felis catus OTUD7B VGNC VGNC:64003
Rattus norvegicus OTUD7B RGD RGD:1308111
Bos taurus OTUD7B VGNC VGNC:32500
Canis familiaris OTUD7B VGNC VGNC:44191
Others OTUD7B NCBI