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SPSB2 - splA/ryanodine receptor domain and SOCS box containing 2 Gene

Also Known as SSB2; GRCC9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84727

About SPSB2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,870,935-6,873,303 (from NCBI)

This gene has 5 transcripts (splice variants), 148 orthologues and 4 paralogues. Broad expression in brain (RPKM 50.3), appendix (RPKM 44.2) and 19 other tissues.

Summary

This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SPSB2 Products (3)

mRNA	Protein	Name
NM_001146316.2	NP_001139788.1	SPRY domain-containing SOCS box protein 2
NM_001319670.2	NP_001306599.1	SPRY domain-containing SOCS box protein 2
NM_032641.4	NP_116030.1	SPRY domain-containing SOCS box protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15601820	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IPI IPI: Inferred from physical interaction	21199876	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	21199876	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21199876	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytosol	IDA IDA: Inferred from direct assay	21199876	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPSB2 Protein Structure

SPRY

SOCS_box

0
100
200
263 a.a.

Protein Preferred Names	Protein Names
SPRY domain-containing SOCS box protein 2	SPRY domain-containing SOCS box protein SSB-2

SPSB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SPSB2	Q99619	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	SPSB2	Q99619	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	SPSB2	Q99619	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	SPSB2	Q99619	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	SPSB2	Q99619	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	SPSB2	Q99619	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	SPSB2	Q99619	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	33961781
Intra	SPSB2	Q99619	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	15601820
Intra	SPSB2	Q99619	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	19159283
Intra	SPSB2	Q99619	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	SPSB2	Q99619	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	SPSB2	Q99619	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	SPSB2	Q99619	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	SPSB2	Q99619	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	SPSB2	Q99619	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	SPSB2	Q99619	PAWR	Homo sapiens	Q96IZ0	ITC	20561531
Intra	SPSB2	Q99619	PAWR	Homo sapiens	Q96IZ0	Anti Tag CoIP	33961781
Intra	SPSB2	Q99619	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	SPSB2	Q99619	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	SPSB2	Q99619	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	SPSB2	Q99619	PRMT1	Homo sapiens	Q99873	Y2H	23455924
Intra	SPSB2	Q99619	PIK3R3	Homo sapiens	Q92569	Y2H Array	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Congenital Muscular Dystrophy-Dystroglycanopathy A7	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A7 Mddga7 Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease Ispd-Related Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A7
Acute Contagious Conjunctivitis	Pink Eye Contagious Opthalmia Pinkeye Conjunctivitis Keratoconjunctivitis Due To Mycoplasma Conjunctivae
Acute Conjunctivitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P10383	SPSB2-iNOS inhibitory cyclic peptide-1		99.81%	Unkown
HY-P10383A	SPSB2-iNOS inhibitory cyclic peptide-1 TFA		/	Unkown
HY-P10384	SPSB2-iNOS inhibitory cyclic peptide-2	Inhibitor	/	Unkown
HY-P10384A	SPSB2-iNOS inhibitory cyclic peptide-2 TFA		/	Unkown
HY-P10385	SPSB2-iNOS inhibitory cyclic peptide-3		/	Unkown
HY-P10385A	SPSB2-iNOS inhibitory cyclic peptide-3 TFA		/	Unkown
HY-RS13727	SPSB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPSB2	VGNC	VGNC:50141
Rattus norvegicus	SPSB2	RGD	RGD:1310854
Macaca mulatta	SPSB2	VGNC	VGNC:100107
Felis catus	SPSB2	VGNC	VGNC:65655
Mus musculus	SPSB2	MGD	MGI:1315199
Canis familiaris	SPSB2	VGNC	VGNC:49871
Others	SPSB2	NCBI