2. Gene
  3. SPSB2 - splA/ryanodine receptor domain and SOCS box containing 2 Gene

SPSB2 - splA/ryanodine receptor domain and SOCS box containing 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SSB2; GRCC9

Gene ID: 84727 | Gene type: protein coding

About SPSB2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,870,935-6,873,303 (from NCBI)

This gene has 5 transcripts (splice variants), 148 orthologues and 4 paralogues. Broad expression in brain (RPKM 50.3), appendix (RPKM 44.2) and 19 other tissues.

Summary

This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SPSB2 Products(3)

mRNA Protein Name
NM_001146316.2 NP_001139788.1 SPRY domain-containing SOCS box protein 2
NM_001319670.2 NP_001306599.1 SPRY domain-containing SOCS box protein 2
NM_032641.4 NP_116030.1 SPRY domain-containing SOCS box protein 2

SPSB2 Protein Structure

SPRY

SPRY: SPRY domain (87 - 218)

SOCS_box

SOCS_box: SOCS box (224 - 263)

  • 0
  • 100
  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

SPRY domain-containing SOCS box protein 2

SPRY domain-containing SOCS box protein SSB-2

Related Diseases

Diseases Alias
Congenital Muscular Dystrophy-Dystroglycanopathy A7

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A7

Mddga7

Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease Ispd-Related

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A7
Acute Contagious Conjunctivitis

Pink Eye

Contagious Opthalmia

Pinkeye

Conjunctivitis

Keratoconjunctivitis Due To Mycoplasma Conjunctivae
Acute Conjunctivitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13727 SPSB2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SPSB2 VGNC VGNC:50141
Rattus norvegicus SPSB2 RGD RGD:1310854
Macaca mulatta SPSB2 VGNC VGNC:100107
Felis catus SPSB2 VGNC VGNC:65655
Mus musculus SPSB2 MGD MGI:1315199
Canis familiaris SPSB2 VGNC VGNC:49871