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65990

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12

Inhibitors & Agonists

1

Natural
Products

2

Recombinant Proteins

5

Antibodies

8

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173351
    G-6599

    		Epigenetic Reader Domain Cancer
    G-6599 is a monovalent molecular glue-like degrader of SMARCA2/SMARCA4. G-6599 covalently binds to a specific cysteine residue of the E3 ligase FBXO22 in a biotransformation-independent manner, promotes the formation of a ternary complex with SMARCA2/A4, and achieves efficient and specific degradation of the two proteins via the ubiquitin-proteasome pathway. G-6599 is applicable to the research of androgen-dependent prostate cancer and mutant non-small cell lung cancer .
    G-6599
  • HY-156684
    Nedizantrep

    GDC-6599

    		 TRP Channel Neurological Disease
    GDC-6599 is an orally active TRPA1 inhibitor, with IC50 values of 5.3 nM in humans, 6.6 nM in rats, 9.3 nM in dogs, 7.2 nM in monkeys, and 15 nM in guinea pigs. GDC-6599 can be used in the research of neuropathic pain and respiratory diseases such as asthma and chronic cough .
    Nedizantrep
  • HY-N8743
    Cyclo(Pro-Leu)

    A 65190; Cyclo-(leucyl-prolyl)

    		 Endogenous Metabolite Cancer
    Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer .
    Cyclo(Pro-Leu)
  • HY-47876
    WAY-659590

    		Drug Derivative Others
    2-(((Benzo[d][1,3]dioxol-5-ylmethylene)amino)oxy)-N-(m-tolyl)acetamide is an active molecule.
    WAY-659590
  • HY-R03713
    mmu-miR-6990-5p mimic

    		MicroRNA Cancer
    mmu-miR-6990-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-6990-5p mimic
    mmu-miR-6990-5p mimic
  • HY-R03712A
    mmu-miR-6990-3p agomir

    		MicroRNA Cancer
    mmu-miR-6990-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-6990-3p agomir
    mmu-miR-6990-3p agomir
  • HY-R03712
    mmu-miR-6990-3p mimic

    		MicroRNA Cancer
    mmu-miR-6990-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-6990-3p mimic
    mmu-miR-6990-3p mimic
  • HY-RI03712
    mmu-miR-6990-3p inhibitor

    		MicroRNA Cancer
    mmu-miR-6990-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-6990-3p inhibitor
    mmu-miR-6990-3p inhibitor
  • HY-RI03713A
    mmu-miR-6990-5p antagomir

    		MicroRNA Cancer
    mmu-miR-6990-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-6990-5p antagomir
    mmu-miR-6990-5p antagomir
  • HY-R03713A
    mmu-miR-6990-5p agomir

    		MicroRNA Cancer
    mmu-miR-6990-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-6990-5p agomir
    mmu-miR-6990-5p agomir
  • HY-RI03712A
    mmu-miR-6990-3p antagomir

    		MicroRNA Cancer
    mmu-miR-6990-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-6990-3p antagomir
    mmu-miR-6990-3p antagomir
  • HY-RI03713
    mmu-miR-6990-5p inhibitor

    		MicroRNA Cancer
    mmu-miR-6990-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-6990-5p inhibitor
    mmu-miR-6990-5p inhibitor

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