PLAAT4 - phospholipase A and acyltransferase 4 Gene

Also Known as RIG1; TIG3; HRSL4; HRASLS4; PLAAT-4; RARRES3; PLA1/2-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5920

About PLAAT4

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:63,536,808-63,546,458 (from NCBI)

This gene has 5 transcripts (splice variants), 73 orthologues and 7 paralogues. Ubiquitous expression in small intestine (RPKM 43.2), duodenum (RPKM 36.6) and 24 other tissues.

Summary

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear Receptor Proteins that are members of the steroid and Thyroid Hormone Receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]

PLAAT4 Products (1)

mRNA Protein Name
NM_004585.5 NP_004576.2 phospholipase A and acyltransferase 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acyltransferase activity IDA
IDA: Inferred from direct assay
22825852 GOA
enables phospholipase A1 activity IDA
IDA: Inferred from direct assay
22825852 GOA
enables phospholipase A2 activity IDA
IDA: Inferred from direct assay
20100577 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17762858 GOA
Biological Process GO Annotation Evidence References Source
involved in N-acylphosphatidylethanolamine metabolic process IDA
IDA: Inferred from direct assay
22825852 GOA
involved in phospholipid metabolic process IDA
IDA: Inferred from direct assay
20100577 GOA
involved in positive regulation of keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
17762858 GOA
involved in positive regulation of protein-glutamine gamma-glutamyltransferase activity IMP
IMP: Inferred from mutant phenotype
17762858 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
17762858 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAAT4 Protein Structure

LRAT

LRAT: Lecithin retinol acyltransferase (5 - 125)

  • 0
  • 100
  • 164 a.a.
Protein Preferred Names Protein Names

phospholipase A and acyltransferase 4

  • HRAS-like suppressor 4

PLAAT4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLAAT4 Q9UL19 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
Intra
PLAAT4 Q9UL19 SGTA Homo sapiens O43765
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Exocervical Carcinoma

  • Carcinoma Of Exocervix

  • Carcinoma Of The Exocervix
Poland Syndrome

  • Poland Anomaly

  • Poland Sequence

  • Poland Syndactyly

  • Poland'S Syndrome

  • Poland'S Anomaly

  • Poland'S Syndactyly

  • Acro-Pectoro-Renal Field Defect

  • Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys

  • Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand

  • Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand
Psoriasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10639 PLAAT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown