TNNI1 - troponin I1, slow skeletal type Gene

Also Known as TNN1; SSTNI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7135

About TNNI1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:201,403,784-201,421,730 (from NCBI)

This gene has 7 transcripts (splice variants), 248 orthologues and 2 paralogues. Biased expression in esophagus (RPKM 22.0), prostate (RPKM 20.7) and 2 other tissues.

Summary

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]

TNNI1 Products (1)

mRNA	Protein	Name
NM_003281.4	NP_003272.3	troponin I, slow skeletal muscle

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNNI1 Protein Structure

Troponin

0
100
187 a.a.

Protein Preferred Names	Protein Names
troponin I, slow skeletal muscle	troponin I type 1 (skeletal, slow)

TNNI1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNNI1	P19237	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	32296183
Intra	TNNI1	P19237	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	TNNI1	P19237	CABP5	Homo sapiens	Q9NP86	Validated Y2H	32296183
Intra	TNNI1	P19237	MFAP1	Homo sapiens	P55081	Validated Y2H	32296183
Intra	TNNI1	P19237	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	TNNI1	P19237	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	TNNI1	P19237	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	TNNI1	P19237	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	TNNI1	P19237	C2orf68	Homo sapiens	Q2NKX9	Validated Y2H	32296183
Intra	TNNI1	P19237	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	TNNI1	P19237	ESRRG	Homo sapiens	P62508-3	Validated Y2H	32296183
Intra	TNNI1	P19237	CABP2	Homo sapiens	Q9NPB3	Validated Y2H	32296183
Intra	TNNI1	P19237	SPANXN2	Homo sapiens	Q5MJ10	Validated Y2H	32296183
Intra	TNNI1	P19237	EFCAB2	Homo sapiens	Q5VUJ9-2	Validated Y2H	32296183
Intra	TNNI1	P19237	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	TNNI1	P19237	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	TNNI1	P19237	TNNT2	Homo sapiens	P45379-11	Validated Y2H	32296183
Intra	TNNI1	P19237	DCAF11	Homo sapiens	Q8TEB1	Validated Y2H	32296183
Intra	TNNI1	P19237	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	32296183
Intra	TNNI1	P19237	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	TNNI1	P19237	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	TNNI1	P19237	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	TNNI1	P19237	TNNC1	Homo sapiens	P63316	Validated Y2H	32296183
Intra	TNNI1	P19237	TNNC1	Homo sapiens	P63316	Complementation	32296183
Intra	TNNI1	P19237	TNNC1	Homo sapiens	P63316	Y2H Prey Pooling	32296183
Intra	TNNI1	P19237	TNNC1	Homo sapiens	P63316	Y2H Array	32296183
Intra	TNNI1	P19237	TNNC1	Homo sapiens	P63316	Y2H Array	21988832
Intra	TNNI1	P19237	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	32296183
Intra	TNNI1	P19237	SAT1	Homo sapiens	P21673	Validated Y2H	32296183
Intra	TNNI1	P19237	SAT1	Homo sapiens	P21673	Y2H Array	32296183
Intra	TNNI1	P19237	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	TNNI1	P19237	ZNF76	Homo sapiens	P36508	Validated Y2H	32296183
Intra	TNNI1	P19237	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	32296183
Intra	TNNI1	P19237	L3MBTL2	Homo sapiens	Q969R5	Validated Y2H	32296183
Intra	TNNI1	P19237	CEP19	Homo sapiens	Q96LK0	Validated Y2H	32296183
Intra	TNNI1	P19237	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
Intra	TNNI1	P19237	MNS1	Homo sapiens	Q8NEH6	Validated Y2H	32296183
Intra	TNNI1	P19237	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	TNNI1	P19237	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	TNNI1	P19237	EIF1AD	Homo sapiens	Q8N9N8	Validated Y2H	32296183
Intra	TNNI1	P19237	EAF1	Homo sapiens	Q96JC9	Validated Y2H	32296183
Intra	TNNI1	P19237	PIK3R3	Homo sapiens	Q92569	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nemaline Myopathy 5	Amish Nemaline Myopathy NEM5 Anm Nemaline Myopathy, Amish Type Nemaline Myopathy 5, Amish Type Nemaline Myopathy, Caused By Mutation In The Troponin T1 Gene Nemaline Myopathy, Type 5 Nemaline Myopathy Amish Type Tnnt1-Related Nemaline Myopathy Myopathy, Nemaline, Type 5
Myasthenic Syndrome, Congenital, 20, Presynaptic	Congenital Myasthenic Syndrome 20 CMS20 Congenital Myasthenic Syndrome 20 Presynaptic Myasthenic Syndrome, Congenital, Type 20, Presynaptic
Severe Congenital Neutropenia 1
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome	Jacobs Syndrome Arthropathy-Camptodactyly Syndrome Pericarditis-Arthropathy-Camptodactyly Syndrome Xyy Syndrome Pac Syndrome Cacp Syndrome CACP Fibrosing Serositis, Familial Camptodactyly-Arthropathy-Pericarditis Syndrome Cap Syndrome 47, Xyy Syndrome 47,Xyy Syndrome Double Y Syndrome Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome Hypertrophic Synovitis, Congenital Familial Congenital Familial Hypertrophic Synovitis Xyy Karyotype Y Disomy Yy Syndrome Familial Fibrosing Serositis Disomy Y Double Y Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome Arthropathy Camptodactyly Syndrome Camptodactyly Arthropathy Pericarditis Syndrome Pericarditis Arthropathy Camptodactyly Syndrome Jacob'S Syndrome 47,Xyy Cdags Syndrome
Nemaline Myopathy 2	NEM2 Nemaline Myopathy 2, Autosomal Recessive Nemaline Myopathy, Type 2 Neb-Related Nemaline Myopathy Myopathy, Nemaline, Type 2
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Congenital Fiber-Type Disproportion	Congenital Fiber Type Disproportion Cftdm Congenital Myopathy With Fiber Type Disproportion Cftd Congenital Fiber-Type Disproportion Myopathy Fiber-Type Disproportion Myopathy, Congenital Myopathy, Congenital With Fiber-Type Disproportion
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14850	TNNI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNNI1	MGD	MGI:105073
Macaca mulatta	TNNI1	VGNC	VGNC:100163
Felis catus	TNNI1	VGNC	VGNC:107955
Bos taurus	TNNI1	VGNC	VGNC:36191
Canis familiaris	TNNI1	VGNC	VGNC:47688
Rattus norvegicus	TNNI1	RGD	RGD:621765
Others	TNNI1	NCBI