MNS1 - meiosis specific nuclear structural 1 Gene

Also Known as HTX9; SPATA40

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55329

About MNS1

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:56,428,724-56,465,137 (from NCBI)

This gene has 3 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Biased expression in testis (RPKM 28.7), kidney (RPKM 5.6) and 13 other tissues.

Summary

This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]

MNS1 Products (1)

mRNA Protein Name
NM_018365.4 NP_060835.1 meiosis-specific nuclear structural protein 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
22396656 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30148830 GOA
Cellular Component GO Annotation Evidence References Source
located in axonemal microtubule IDA
IDA: Inferred from direct assay
36191189 GOA
located in axoneme IDA
IDA: Inferred from direct assay
30148830 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MNS1 Protein Structure

TPH

TPH: Trichohyalin-plectin-homology domain (116 - 465)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
Protein Preferred Names Protein Names

meiosis-specific nuclear structural protein 1

  • spermatogenesis associated 40

MNS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MNS1 Q8NEH6 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
32296183
Intra
MNS1 Q8NEH6 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
MNS1 Q8NEH6 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 CEP63 Homo sapiens Q96MT8-3
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 CEP63 Homo sapiens Q96MT8-3
Validated Y2H
32296183
Intra
MNS1 Q8NEH6 CEP63 Homo sapiens Q96MT8-3
Y2H Array
32296183
Intra
MNS1 Q8NEH6 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra
MNS1 Q8NEH6 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 IQCB1 Homo sapiens Q15051-2
Y2H Array
32296183
Intra
MNS1 Q8NEH6 IQCB1 Homo sapiens Q15051-2
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 FCHSD2 Homo sapiens O94868-3
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 FCHSD2 Homo sapiens O94868-3
Y2H Array
32296183
Intra
MNS1 Q8NEH6 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
MNS1 Q8NEH6 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
MNS1 Q8NEH6 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
MNS1 Q8NEH6 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
MNS1 Q8NEH6 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 EP400 Homo sapiens A0A0A0MR80
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 EP400 Homo sapiens A0A0A0MR80
Y2H Array
32296183
Intra
MNS1 Q8NEH6 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
MNS1 Q8NEH6 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
MNS1 Q8NEH6 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
MNS1 Q8NEH6 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
Intra
MNS1 Q8NEH6 CHAT Homo sapiens P28329-3
Y2H Array
32814053
Intra
MNS1 Q8NEH6 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
Intra
MNS1 Q8NEH6 KIAA0753 Homo sapiens Q2KHM9
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 KIAA0753 Homo sapiens Q2KHM9
Y2H Array
32296183
Intra
MNS1 Q8NEH6 KRT75 Homo sapiens O95678
Validated Y2H
32296183
Intra
MNS1 Q8NEH6 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
MNS1 Q8NEH6 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
MNS1 Q8NEH6 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
MNS1 Q8NEH6 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
MNS1 Q8NEH6 AATF Homo sapiens Q9NY61
Y2H Array
32296183
Intra
MNS1 Q8NEH6 AATF Homo sapiens Q9NY61
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 AATF Homo sapiens Q9NY61
Validated Y2H
32296183
Intra
MNS1 Q8NEH6 CCND3 Homo sapiens P30281
Y2H Array
32296183
Intra
MNS1 Q8NEH6 CCND3 Homo sapiens P30281
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 THOC7 Homo sapiens Q6I9Y2
Y2H Array
32296183
Intra
MNS1 Q8NEH6 THOC7 Homo sapiens Q6I9Y2
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 STMN3 Homo sapiens Q9NZ72
Y2H Array
32296183
Intra
MNS1 Q8NEH6 STMN3 Homo sapiens Q9NZ72
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 STMN3 Homo sapiens Q9NZ72
Validated Y2H
32296183
Intra
MNS1 Q8NEH6 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra
MNS1 Q8NEH6 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 TNNI1 Homo sapiens P19237
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 TNNI1 Homo sapiens P19237
Y2H Array
32296183
Intra
MNS1 Q8NEH6 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
Intra
MNS1 Q8NEH6 TNNI2 Homo sapiens P48788
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 TNNI2 Homo sapiens P48788
Y2H Array
32296183
Intra
MNS1 Q8NEH6 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
MNS1 Q8NEH6 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
MNS1 Q8NEH6 SNX32 Homo sapiens Q86XE0
Y2H Array
32296183
Intra
MNS1 Q8NEH6 SNX32 Homo sapiens Q86XE0
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 TTC23 Homo sapiens Q5W5X9-3
Y2H Array
32296183
Intra
MNS1 Q8NEH6 TTC23 Homo sapiens Q5W5X9-3
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
Intra
MNS1 Q8NEH6 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Heterotaxy, Visceral, 9, Autosomal, With Male Infertility

  • HTX9
Situs Inversus

  • Situs Inversus Viscerum

  • Laterality Sequence

  • Complete Transposition

  • Siv
Dextrocardia With Situs Inversus

  • Situs Inversus Totalis

  • Complete Situs Inversus

  • Complete Situs Inversus Viscerum

  • Situs Inversus
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Osteogenesis Imperfecta, Type Xiv

  • Osteogenesis Imperfecta Type 14

  • OI14

  • Osteogenesis Imperfecta Type Xiv

  • Oi, Type Xiv

  • Osteogenesis Imperfecta 14

  • Oi Type Xiv

  • Oi-Xiv
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Infertility
Borderline Glaucoma

  • Preglaucoma
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

  • Polycystic Kidney Disease 2

  • PKD2

  • Polycystic Kidney Disease, Adult, Type Ii

  • Apkd2

  • Polycystic Kidney Disease, Type 2

  • Adpkd2

  • Adult Polycystic Kidney Disease Type 2

  • Autosomal Dominant Polycystic Kidney Disease 2

  • Pkd-2

  • Polycystic Kidney Disease Adult Type Ii

  • Polycystic Kidney Type 2 Autosomal Dominant Disease

  • Kidney Disease, Polycystic, Type 2
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08569 MNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MNS1 RGD RGD:1549718
Macaca mulatta MNS1 VGNC VGNC:74861
Canis familiaris MNS1 VGNC VGNC:43297
Mus musculus MNS1 MGD MGI:107933
Bos taurus MNS1 VGNC VGNC:31539
Felis catus MNS1 VGNC VGNC:104496
Others MNS1 NCBI