THOC7 - THO complex subunit 7 Gene

Also Known as fSAP24; hTREX30; NIF3L1BP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80145

About THOC7

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:63,833,870-63,864,484 (from NCBI)

This gene has 7 transcripts (splice variants) and 238 orthologues. Ubiquitous expression in adrenal (RPKM 20.0), colon (RPKM 19.8) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Involved in mRNA export from nucleus and viral mRNA export from host cell nucleus. Located in cytosol and nuclear speck. Part of THO complex part of transcription export complex. Colocalizes with chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

THOC7 Products (3)

mRNA Protein Name
NM_001285387.3 NP_001272316.1 THO complex subunit 7 homolog isoform 2
NM_001285404.2 NP_001272333.1 THO complex subunit 7 homolog isoform 2
NM_025075.4 NP_079351.2 THO complex subunit 7 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12951069 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
17190602 GOA
Cellular Component GO Annotation Evidence References Source
part of THO complex IDA
IDA: Inferred from direct assay
15998806 GOA
part of THO complex part of transcription export complex IDA
IDA: Inferred from direct assay
15998806 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12951069 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12951069 GOA
part of transcription export complex IDA
IDA: Inferred from direct assay
15833825 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOC7 Protein Structure

THOC7

THOC7: Tho complex subunit 7 (7 - 140)

  • 0
  • 100
  • 204 a.a.
Protein Preferred Names Protein Names

THO complex subunit 7 homolog

  • NIF3L1-binding protein 1

THOC7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
THOC7 Q6I9Y2 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra
THOC7 Q6I9Y2 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
THOC7 Q6I9Y2 THOC5 Homo sapiens Q13769
Anti Tag CoIP
26496610
Intra
THOC7 Q6I9Y2 THOC5 Homo sapiens Q13769
Anti Tag CoIP
19059247
Intra
THOC7 Q6I9Y2 THOC5 Homo sapiens Q13769
Pull Down
19059247
Intra
THOC7 Q6I9Y2 MNS1 Homo sapiens Q8NEH6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ogden Syndrome

  • OGDNS

  • N-Terminal Acetyltransferase Deficiency

  • NATD

  • N-Alpha-Acetyltransferase

  • X-Linked Malformation And Infantile Lethality Syndrome

  • Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Microphthalmia, Syndromic 1

  • MCOPS1

  • Lenz Microphthalmia Syndrome

  • Lenz Dysplasia

  • Mcops4

  • Syndromic Microphthalmia 1

  • Lenz Microphthalmia

  • Maa

  • Microphthalmia Or Anophthalmos With Associated Anomalies

  • Syndromic Microphthalmia Type 4

  • Microphthalmia, Syndromic 4

  • Microphthalmia, Syndromic 4, Formerly

  • Mcops4, Formerly

  • Anop1, Formerly

  • Maa, Formerly

  • Lenz Type Microphthalmia

  • Syndromic Microphthalmia 4

  • Microphthalmia Lenz Type

  • Microphthalmia Syndromic 1

  • Syndromic Microphthalmia Type 1

  • Microphthalmia Syndromic 4

  • Microphthalmia With Ankyloblepharon And Intellectual Disability

  • Microphthalmia, Lenz Type

  • Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

  • Microphthalmia, Syndromic, 1

  • Anop1

  • Microphthalmia, Syndromic, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14496 THOC7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta THOC7 VGNC VGNC:79824
Rattus norvegicus THOC7 RGD RGD:1305475
Bos taurus THOC7 VGNC VGNC:106977
Felis catus THOC7 VGNC VGNC:66169
Mus musculus THOC7 MGD MGI:1913481
Canis familiaris THOC7 VGNC VGNC:58337
Others THOC7 NCBI