THOC5 - THO complex subunit 5 Gene

Also Known as Fmip; PK1.3; fSAP79; C22orf19

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8563

About THOC5

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:29,505,879-29,553,757 (from NCBI)

This gene has 17 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in testis (RPKM 10.3), endometrium (RPKM 6.9) and 25 other tissues.

Summary

Predicted to enable mRNA binding activity. Involved in several processes, including monocyte differentiation; negative regulation of DNA damage checkpoint; and viral mRNA export from host cell nucleus. Located in nucleoplasm. Part of THO complex part of transcription export complex. Colocalizes with chromosome, telomeric region. Implicated in breast carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

THOC5 Products (4)

mRNA Protein Name
NM_001002877.2 NP_001002877.1 THO complex subunit 5 homolog
NM_001002878.1 NP_001002878.1 THO complex subunit 5 homolog
NM_001002879.1 NP_001002879.1 THO complex subunit 5 homolog
NM_003678.5 NP_003669.4 THO complex subunit 5 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19059247 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
17190602 GOA
involved in mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
22144908 GOA
involved in monocyte differentiation IDA
IDA: Inferred from direct assay
19015024 GOA
Cellular Component GO Annotation Evidence References Source
part of THO complex IDA
IDA: Inferred from direct assay
15998806 GOA
part of THO complex part of transcription export complex IDA
IDA: Inferred from direct assay
15998806 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19059247 GOA
part of transcription export complex IDA
IDA: Inferred from direct assay
15833825 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOC5 Protein Structure

FimP

FimP: Fms-interacting protein (96 - 452)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
Protein Preferred Names Protein Names

THO complex subunit 5 homolog

  • Fms-interacting protein

THOC5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
THOC5 Q13769 THOC1 Homo sapiens Q96FV9
Anti Tag CoIP
23299939
Intra
THOC5 Q13769 THOC1 Homo sapiens Q96FV9
Anti Tag CoIP
19059247
Intra
THOC5 Q13769 THOC1 Homo sapiens Q96FV9
Anti Tag CoIP
26496610
Intra
THOC5 Q13769 THOC7 Homo sapiens Q6I9Y2
Anti Tag CoIP
19059247
Intra
THOC5 Q13769 THOC7 Homo sapiens Q6I9Y2
IF
19059247
Intra
THOC5 Q13769 THOC7 Homo sapiens Q6I9Y2
Pull Down
19059247
Intra
THOC5 Q13769 THOC7 Homo sapiens Q6I9Y2
Anti Tag CoIP
26496610
Intra
THOC5 Q13769 TAP1 Homo sapiens Q03518
Pull Down
19165146
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14494 THOC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta THOC5 VGNC VGNC:79178
Felis catus THOC5 VGNC VGNC:80500
Bos taurus THOC5 VGNC VGNC:35841
Mus musculus THOC5 MGD MGI:1351333
Canis familiaris THOC5 VGNC VGNC:47351
Rattus norvegicus THOC5 RGD RGD:1304991
Others THOC5 NCBI