STMN3 - stathmin 3 Gene

Also Known as SCLIP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50861

About STMN3

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,639,712-63,653,424 (from NCBI)

This gene has 5 transcripts (splice variants), 174 orthologues and 4 paralogues. Broad expression in brain (RPKM 62.0), thyroid (RPKM 16.1) and 20 other tissues.

Summary

This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

STMN3 Products (2)

mRNA Protein Name
NM_001276310.2 NP_001263239.1 stathmin-3 isoform 2
NM_015894.4 NP_056978.2 stathmin-3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STMN3 Protein Structure

Stathmin

Stathmin: Stathmin family (39 - 177)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

stathmin-3

  • SCG10-like protein

STMN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STMN3 Q9NZ72 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
STMN3 Q9NZ72 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13945 STMN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22837 Stmn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STMN3 VGNC VGNC:81229
Canis familiaris STMN3 VGNC VGNC:46927
Bos taurus STMN3 VGNC VGNC:35405
Mus musculus STMN3 MGD MGI:1277137
Rattus norvegicus STMN3 RGD RGD:3628
Macaca mulatta STMN3 VGNC VGNC:108063
Others STMN3 NCBI