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AATF - apoptosis antagonizing transcription factor Gene

Also Known as DED; BFR2; CHE1; CHE-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26574

About AATF

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,948,954-37,056,871 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in lymph node (RPKM 16.6), appendix (RPKM 15.2) and 25 other tissues.

Summary

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell Apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced Apoptosis. [provided by RefSeq, Jul 2008]

AATF Products (2)

mRNA	Protein	Name
NM_001411094.1	NP_001398023.1	protein AATF isoform 2
NM_012138.4	NP_036270.1	protein AATF isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables leucine zipper domain binding	IPI IPI: Inferred from physical interaction	10580117	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10783144	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14627703	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10580117	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AATF Protein Structure

AATF-Che1

TRAUB

0
100
200
300
400
500
560 a.a.

Protein Preferred Names	Protein Names
protein AATF	rb-binding protein Che-1

AATF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AATF	Q9NY61	CHEK2	Homo sapiens	O96017	Protein Kinase Assay	17157788
Intra	AATF	Q9NY61	TADA2B	Homo sapiens	Q86TJ2	Confocal	29232376
Intra	AATF	Q9NY61	TADA2B	Homo sapiens	Q86TJ2	Anti Tag CoIP	29232376
Intra	AATF	Q9NY61	SP1	Homo sapiens	P08047	Pull Down	12847090
Intra	AATF	Q9NY61	TADA3	Homo sapiens	O75528	Anti Tag CoIP	29232376
Intra	AATF	Q9NY61	KAT2A	Homo sapiens	Q92830	Confocal	29232376
Intra	AATF	Q9NY61	KAT2A	Homo sapiens	Q92830	Anti Tag CoIP	29232376
Intra	AATF	Q9NY61	ATM	Homo sapiens	Q13315	Anti Bait CoIP	17157788
Intra	AATF	Q9NY61	RELA	Homo sapiens	Q04206	Anti Bait CoIP	17157788
Intra	AATF	Q9NY61	TADA2A	Homo sapiens	O75478	Anti Tag CoIP	29232376
Intra	AATF	Q9NY61	TADA2A	Homo sapiens	O75478	Confocal	29232376
Cross	AATF	Q9NY61	Myl12a	Mus musculus	Q6ZWQ9	Anti Tag CoIP	22909821
Intra	AATF	Q9NY61	NGDN	Homo sapiens	Q8NEJ9	Anti Tag CoIP	35271311
Intra	AATF	Q9NY61	NGDN	Homo sapiens	Q8NEJ9	Y2H Array	25416956
Intra	AATF	Q9NY61	NGDN	Homo sapiens	Q8NEJ9	Crosslink	30021884
Intra	AATF	Q9NY61	NGDN	Homo sapiens	Q8NEJ9	Y2H Prey Pooling	25416956
Intra	AATF	Q9NY61	NGDN	Homo sapiens	Q8NEJ9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Flinders Island Spotted Fever	Fisf Thai Tick Typhus
Wolfram Syndrome 1	WFS1 Didmoad Wfs Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome Wolfram Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00034	AATF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20688	Aatf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27199	Aatf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AATF	VGNC	VGNC:37420
Felis catus	AATF	VGNC	VGNC:98754
Macaca mulatta	AATF	VGNC	VGNC:69475
Bos taurus	AATF	VGNC	VGNC:25452
Rattus norvegicus	AATF	RGD	RGD:620685
Mus musculus	AATF	MGD	MGI:1929608
Others	AATF	NCBI