2. Gene
  3. AATF - apoptosis antagonizing transcription factor Gene

AATF - apoptosis antagonizing transcription factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DED; BFR2; CHE1; CHE-1

Gene ID: 26574 | Gene type: protein coding

About AATF

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,948,954-37,056,871 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in lymph node (RPKM 16.6), appendix (RPKM 15.2) and 25 other tissues.

Summary

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell Apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced Apoptosis. [provided by RefSeq, Jul 2008]

AATF Products(2)

mRNA Protein Name
NM_001411094.1 NP_001398023.1 protein AATF isoform 2
NM_012138.4 NP_036270.1 protein AATF isoform 1

AATF Protein Structure

AATF-Che1

AATF-Che1: Apoptosis antagonizing transcription factor (220 - 373)

TRAUB

TRAUB: Apoptosis-antagonizing transcription factor, C-terminal (464 - 548)

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  • 560 a.a.
Protein Preferred Names Protein Names

protein AATF

rb-binding protein Che-1

Related Diseases

Diseases Alias
Flinders Island Spotted Fever

Fisf

Thai Tick Typhus
Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00034 AATF Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AATF VGNC VGNC:37420
Felis catus AATF VGNC VGNC:98754
Macaca mulatta AATF VGNC VGNC:69475
Bos taurus AATF VGNC VGNC:25452
Rattus norvegicus AATF RGD RGD:620685
Mus musculus AATF MGD MGI:1929608