KAT2A - lysine acetyltransferase 2A Gene

Also Known as GCN5; hGCN5; GCN5L2; PCAF-b

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2648

About KAT2A

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,113,111-42,121,367 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 11 paralogues. Ubiquitous expression in ovary (RPKM 41.6), adrenal (RPKM 30.6) and 25 other tissues.

Summary

KAT2A, or GCN5, is a Histone Acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

KAT2A Products (3)

mRNA	Protein	Name
XM_006721818.5	XP_006721881.1	histone acetyltransferase KAT2A isoform X1
NM_021078.3	NP_066564.2	histone acetyltransferase KAT2A isoform 1
NM_001376227.1	NP_001363156.1	histone acetyltransferase KAT2A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17301242	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	29211711	GOA
enables histone H3 acetyltransferase activity	IDA IDA: Inferred from direct assay	18838386	GOA
enables histone H3K9 acetyltransferase activity	IDA IDA: Inferred from direct assay	21131905	GOA
enables histone acetyltransferase activity	IDA IDA: Inferred from direct assay	10373431	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	12887892	GOA
enables histone glutaryltransferase activity	IDA IDA: Inferred from direct assay	31542297	GOA
enables histone succinyltransferase activity	IDA IDA: Inferred from direct assay	29211711	GOA
enables peptide-lysine-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	16753578	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17664281	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11564863	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in internal peptidyl-lysine acetylation	IDA IDA: Inferred from direct assay	27796307	GOA
involved in negative regulation of centriole replication	IDA IDA: Inferred from direct assay	27796307	GOA
involved in negative regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	16753578	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18838386	GOA
involved in peptidyl-lysine glutarylation	IDA IDA: Inferred from direct assay	31542297	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	29973595	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	29211711	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19936620	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19103755	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20562830	GOA
acts upstream of or within regulation of protein stability	IMP IMP: Inferred from mutant phenotype	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA
involved in regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	20562830	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	18838386	GOA
part of SAGA complex	IDA IDA: Inferred from direct assay	11564863	GOA
located in centrosome	IDA IDA: Inferred from direct assay	27796307	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	29973595	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11564863	GOA
part of oxoglutarate dehydrogenase complex	IDA IDA: Inferred from direct assay	29211711	GOA
part of transcription factor TFTC complex	IDA IDA: Inferred from direct assay	10373431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KAT2A Protein Structure

PCAF_N

Acetyltransf_7

Bromodomain

0
200
400
600
800
837 a.a.

Protein Preferred Names	Protein Names
histone acetyltransferase KAT2A	GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2 General control of amino acid synthesis, yeast, homolog-like 2 K(lysine) acetyltransferase 2A STAF97 general control of amino acid synthesis protein 5-like 2 histone acetyltransferase GCN5 histone glutaryltransferase KAT2A histone succinyltransferase KAT2A hsGCN5

KAT2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	KAT2A	Q92830	N	SARS-CoV-2	P0DTC9	Acetylase Assay	33894414
Intra	KAT2A	Q92830	ZZZ3	Homo sapiens	Q8IYH5	Anti Bait CoIP	20562830
Intra	KAT2A	Q92830	AATF	Homo sapiens	Q9NY61	Y2H	29232376
Intra	KAT2A	Q92830	WDHD1	Homo sapiens	O75717	Anti Bait CoIP	21725360

Cross: Cross-species interaction Intra: Intraspecies interaction

KAT2A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83155	KAT2A Antibody (YA2900)	WB, IP	Human
HY-P83155A	KAT2A Antibody (YA2900)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Retinal Degeneration	Degeneration Of Retina
Chromosome 16p13.3 Deletion Syndrome, Proximal	Rubinstein-Taybi Syndrome Broad Thumb-Hallux Syndrome Chromosome 16p13.3 Deletion Syndrome Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion Rubinstein Syndrome Broad Thumbs-Halluces Syndrome Rsts Rubinstein-Taybi Deletion Syndrome Rsts Deletion Syndrome Proximal Chromosome 16p13.3 Deletion Syndrome 16p13.3 Deletion Syndrome Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation Rts
Spinocerebellar Ataxia 7	Spinocerebellar Ataxia Type 7 SCA7 Opca3 Opca Iii Olivopontocerebellar Atrophy Iii Opca With Retinal Degeneration Opca With Macular Degeneration And External Ophthalmoplegia Adca, Type Ii Autosomal Dominant Cerebellar Ataxia Type 2 Olivopontocerebellar Atrophy 3 Autosomal Dominant Cerebellar Ataxia, Type Ii Autosomal Dominant Cerebellar Ataxia Type Ii Adca2 Adcaii Ataxia With Pigmentary Retinopathy Cerebellar Syndrome-Pigmentary Maculopathy Syndrome Olivopontocerebellar Atrophy With Retinal Degeneration Spinocerebellar Ataxia-7 Ataxia, Spinocerebellar, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173158	AUR1545	Inhibitor	99.58%	Unkown
HY-122822	GSK699		98.80%	Unkown
HY-168428	CHI-KAT8i5		98.00%	Unkown
HY-RS07074	KAT2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07075	Kat2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181695	PROTAC KAT2A/B degrader-1	Degrader	/	Unkown
HY-RS07076	Kat2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W1122565	KAT2A/B ligand 1	Ligand	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KAT2A	RGD	RGD:1307242
Canis familiaris	KAT2A	VGNC	VGNC:42209
Felis catus	KAT2A	VGNC	VGNC:63023
Mus musculus	KAT2A	MGD	MGI:1343101
Bos taurus	KAT2A	VGNC	VGNC:30398
Others	KAT2A	NCBI