KAT2A - lysine acetyltransferase 2A Gene

Homo sapiens

Also known as GCN5; hGCN5; GCN5L2; PCAF-b

Gene ID: 2648 | Gene type: protein coding

About KAT2A

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,113,111-42,121,367 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 11 paralogues. Ubiquitous expression in ovary (RPKM 41.6), adrenal (RPKM 30.6) and 25 other tissues.

Summary

KAT2A, or GCN5, is a Histone Acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

KAT2A Products(3)

mRNA	Protein	Name
XM_006721818.5	XP_006721881.1	histone acetyltransferase KAT2A isoform X1
NM_021078.3	NP_066564.2	histone acetyltransferase KAT2A isoform 1
NM_001376227.1	NP_001363156.1	histone acetyltransferase KAT2A isoform 2

KAT2A Protein Structure

PCAF_N

Acetyltransf_7

Bromodomain

0
200
400
600
837 a.a.

Protein Preferred Names

Protein Names

histone acetyltransferase KAT2A

GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2	General control of amino acid synthesis, yeast, homolog-like 2
K(lysine) acetyltransferase 2A	STAF97
general control of amino acid synthesis protein 5-like 2	histone acetyltransferase GCN5
histone glutaryltransferase KAT2A	histone succinyltransferase KAT2A
hsGCN5

Related Diseases

Diseases

Alias

Retinal Degeneration

Degeneration Of Retina

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation
Rts

Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Type 7	SCA7
Opca3	Opca Iii
Olivopontocerebellar Atrophy Iii	Opca With Retinal Degeneration
Opca With Macular Degeneration And External Ophthalmoplegia	Adca, Type Ii
Autosomal Dominant Cerebellar Ataxia Type 2	Olivopontocerebellar Atrophy 3
Autosomal Dominant Cerebellar Ataxia, Type Ii	Autosomal Dominant Cerebellar Ataxia Type Ii
Adca2	Adcaii
Ataxia With Pigmentary Retinopathy	Cerebellar Syndrome-Pigmentary Maculopathy Syndrome
Olivopontocerebellar Atrophy With Retinal Degeneration	Spinocerebellar Ataxia-7
Ataxia, Spinocerebellar, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS07074	KAT2A Human Pre-designed siRNA Set A	/	Unkown
HY-RS07075	Kat2a Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS07076	Kat2a Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KAT2A	RGD	RGD:1307242
Canis familiaris	KAT2A	VGNC	VGNC:42209
Felis catus	KAT2A	VGNC	VGNC:63023
Mus musculus	KAT2A	MGD	MGI:1343101
Bos taurus	KAT2A	VGNC	VGNC:30398
Others	KAT2A	NCBI

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